Airway Control, Airway Devices, General Anaesthesia
Conditions
Keywords
Sevoflurane, Propofol, Laryngeal Mask Airway, Pediatric Anesthesia, Jaw Relaxation, Elective Surgery
Brief summary
The goal of this clinical trial is to compare two commonly used anesthetic medicines, sevoflurane and propofol, for inserting a laryngeal mask airway (LMA) in children undergoing minor elective surgery. A laryngeal mask airway is a device placed in the throat to help children breathe safely during anesthesia. The main questions this study aims to answer are: * Does sevoflurane produce a faster onset of anesthesia than propofol? * Is there a difference between sevoflurane and propofol in the time required to achieve jaw relaxation for LMA insertion? * Is there a difference between the two medicines in the time required for successful LMA insertion? The researchers hypothesize that children receiving sevoflurane will have a shorter induction time than those receiving propofol. A total of 170 children aged 4 to 12 years who are undergoing minor surgical procedures below the umbilicus will participate in the study. Participants will be randomly assigned to receive either intravenous propofol or inhaled sevoflurane for induction of anesthesia. During the procedure, the anesthesia team will measure the time taken to lose consciousness, the time required to achieve adequate jaw relaxation, and the time needed for successful insertion of the laryngeal mask airway. These measurements will help determine which anesthetic agent provides better conditions for LMA insertion in children.
Interventions
DRUGpropofol
Intravenous propofol 3 mg/kg bolus will be administered for induction of general anesthesia before LMA insertion in pediatric patients.
DRUGSevoflurane
Sevoflurane 7% will be delivered via inhalation in a nitrous oxide/oxygen mixture (2:1) for induction of general anesthesia prior to LMA insertion in pediatric patients.
Sponsors
Children's Hospital and Institute of Child Health, Multan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status 1 and 2 * Undergoing elective minor surgical procedures below umbilicus * Procedure lasting less than 60 min
Exclusion criteria
* Recent respiratory tract infection * Bronchial asthma * Family history of malignant hyperthermia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to Induction of Anesthesia | From administration of the induction agent until loss of consciousness, assessed for up to 5 minutes after induction. | Time (in seconds) measured from administration of the induction agent (propofol or sevoflurane) to loss of consciousness, defined as loss of verbal response and loss of eyelash reflex in pediatric patients undergoing elective surgery for laryngeal mask airway insertion. |
Countries
Pakistan
Contacts
STUDY_CHAIRSyed S Abbas, FCPS
Children's Hospital and Institute of Child Health, Multan
Outcome results
None listed