Aortic Dissection, Loeys-Dietz Syndrome, Marfan Syndrome, Maternal and Neonatal Outcomes, Pregnancy Complication, Vascular Ehlers-Danlos Syndrome
Conditions
Keywords
Aortic Dissection, Pregnancy complication, Maternal and Neonatal Outcomes, Marfan Syndrome, Loeys-Dietz syndrome, Vascular Ehlers-Danlos syndrome
Brief summary
A multicenter observational study on pregnancy-related aortic dissection
Interventions
OTHERIntervention strategies including medication or surgery
Medication or surgery (delivery or surgery first, or single-stage delivery and surgery) is determined based on gestational age and the type of AD, and also in consideration of the decisions made by the patient and their relatives.
Sponsors
DeltaHealth Hospital · Shanghai
The Second Affiliated Hospital of Hainan Medical University
Beijing Anzhen Hospital
West China Hospital
Xiangya Hospital of Central South University
Second Xiangya Hospital of Central South University
Sichuan Provincial People's Hospital
Yantai Yuhuangding Hospital
First Hospital of China Medical University
First Affiliated Hospital Xi'an Jiaotong University
Qinghai Red Cross Hospital
Shanxi Bethune Hospital
Shandong Provincial Hospital
Shengjing Hospital
Zhejiang Provincial People's Hospital
Ningbo Medical Center Lihuili Hospital
Central China Fuwai Hospital of Zhengzhou University
Xiamen Cardiovascular Hospital, Xiamen University
The Central Hospital of Linfen
Shenzhen Sun Yat-sen Cardiovascular Hospital
The Affiliated Hospital Of Guizhou Medical University
The University of Hong Kong-Shenzhen Hospital
Hebei Medical University Fourth Hospital
Second Affiliated Hospital of Nanchang University
Southwest Hospital, China
Gulou Hospital Affiliated to Medical College of Nanjing University
The Second Hospital of Shandong University
First Affiliated Hospital, Sun Yat-Sen University
First Affiliated Hospital of Gannan Medical University
The First Affiliated Hospital of Zhengzhou University
Lanzhou University First Hospital
Peking Union Medical College Hospital
First Affiliated Hospital of Harbin Medical University
The First Hospital of Jilin University
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
RenJi Hospital
Peking University People's Hospital
The First Affiliated Hospital of Guangzhou Medical University
Henan Provincial Chest Hospital
First Affiliated Hospital of Wenzhou Medical University
Shanghai Zhongshan Hospital
Qilu Hospital of Shandong University
The First Affiliated Hospital of Bengbu Medical University
Wannan Medical College Yijishan Hospital
Anhui Provincial Hospital
Shanxi Yuncheng Central Hospital
Liuzhou Workers' Hospital
The Third People's Hospital of Chengdu
Suining Central Hospital
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan TongJi Hospital
Renmin Hospital of Wuhan University
The General Hospital of Southern Theater Command
Xijing Hospital，FMMU
Zunyi Medical College
The Affiliated Hospital of Qingdao University
Shanghai Chest Hospital of Shanghai Jiao Tong University
The First Affiliated Hospital of Anhui Medical University
The People's Hospital of Gaozhou
The Second Hospital of Nanjing Medical University
Nanjing First Hospital, Nanjing Medical University
General Hospital of Ningxia Medical University
Guangdong Provincial People's Hospital
Yan'an Affiliated Hospital of Kunming Medical University
Second Affiliated Hospital of Zhengzhou University
Henan Provincial People's Hospital
Wuhan Asia Heart Hospital
Changhai Hospital
Taihe Hospital affiliated to Hubei University of Medicine
Zhongnan Hospital
Luoyang Central Hospital
People's Hospital of Xinjiang Uygur Autonomous Region
Qingdao Municipal Hospital
The First Affiliated Hospital of Nanchang University
Hainan General Hospital
The First Hospital of Hebei Medical University
Gansu Provincial Hospital
The First Affiliated Hospital of Shanxi Medical University
First Affiliated Hospital of Guangxi Medical University
First Affiliated Hospital of Ningbo University
Fujian Medical University Union Hospital
Huai'an First People's Hospital
Chinese University of Hong Kong
Yichang Central People's Hospital
Zhongshan People's Hospital, Guangdong, China
Shiyan City Renmin Hospital
The First Affiliated Hospital of Dalian Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Aortic dissection is diagnosed based on symptoms and physical findings, and confirmed by computed tomographic angiography (CTA) and/or transthoracic echocardiography * Aortic dissection occurring during pregnancy or within 12 weeks postpartum
Exclusion criteria
* Previous history of aortic dissection, but no new aortic dissection occurring during pregnancy or within 12 weeks postpartum
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early-term mortality of mothers and fetuses (or newborns) | Death within 30 days after treatment. | All-cause mortality within 30 days after treatment. |
| Long-term mortality of mothers and children | Through study completion, an average of 3 years. | All-cause mortality during the follow-up period. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of maternal adverse events | Through study completion, an average of 3 years. | The reinterventions for mothers due to aortic and obstetric conditions. |
| The incidence of neonatal developmental abnormalities | Through study completion, an average of 3 years. | Adverse events occurring in newborns during follow-up, including suspected signs of heritable aortic disease and growth and developmental abnormalities (cerebral palsy, intellectual disabilities, etc.) |
Countries
China
Contacts
CONTACTSu-Wei Chen, MD, PhD
CONTACTWei-Guo Ma, MD, PhD
Outcome results
None listed