Exercise, Healthy Subjects (HS), Hypoxia
Conditions
Brief summary
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).
Interventions
COMBINATION_PRODUCTExercise and hypoxia
Subjects will perform an exercise test while inhaling a hypoxic gas mixture
Sponsors
University Hospital, Grenoble
University Grenoble Alps
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male or female volunteers * Aged 18-55 * Body Mass Index \<30 kg/m² * Participants covered by a social security scheme * Participants capable of signing an informed consent form * Negative pregnancy test and highly effective contraception for women of childbearing age
Exclusion criteria
* Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia * Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle oxygenation | During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test | Measured by NIRS in % saturation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gas exchange | During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test | Oxygen consumption and cardon dioxide production measured at the mouth, measured in ml/min |
| Heart rate | During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test | Measured by ECG in bpm |
| Limb blood flow | During 5 minutes before starting the exercise test, continuously during the exercise test and during 10 minutes immediatly after the end of the exercise test | Measured by Doppler ultrasound in ml/min |
Countries
France
Contacts
CONTACTSamuel Vergès
Outcome results
None listed