Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock

Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock: A Prospective Observational Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07670390

Enrollment

Registered

2026-06-26

Start date

2026-07-01

Completion date

2028-06-01

Last updated

2026-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shock

Keywords

shock, tissue perfusion pressure

Brief summary

This prospective observational study aims to evaluate the ability of tissue perfusion pressure (TPP) to predict fluid responsiveness in critically ill patients with shock and tissue hypoperfusion. Eligible patients requiring fluid resuscitation will undergo a standardized fluid challenge test. Hemodynamic parameters, including cardiac output and TPP, will be recorded before and after fluid administration. Fluid responsiveness will be defined according to the change in cardiac output following fluid loading. The study will assess the correlation between changes in TPP and cardiac output and evaluate the diagnostic performance of TPP for predicting fluid responsiveness. The results may support the use of TPP as a practical and physiologically relevant parameter for individualized fluid management in patients with shock.

Interventions

BEHAVIORALWhen the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Age ≥18 years * Admitted to the Intensive Care Unit (ICU) * Diagnosed with shock and evidence of tissue hypoperfusion * Judged by the treating physician to require fluid resuscitation * Receiving invasive hemodynamic monitoring * Written informed consent obtained from the patient or legally authorized representative

Exclusion criteria

* Pregnancy * Immediate requirement for extracorporeal life support, including: VV-ECMO, VA-ECMO, Ventricular assist devices * Expected survival less than 72 hours * Absence of invasive arterial pressure monitoring or arterial waveform availability \<25% * Any condition deemed unsuitable for study participation by the investigator.

Design outcomes

Primary

Measure	Time frame
Δ Cardiac output	Periprocedural
Δ Tissue perfusion pressure	Periprocedural

Contacts

CONTACTJingyuan Xu

xujingyuanmail@163.com8602583262550

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 27, 2026