Minimally Invasive Coronary Surgery, Quantitative Flow Reserve, Radial Artery
Conditions
Keywords
Quantitative Flow Reserve, minimally invasive coronary surgery, Radial Artery
Brief summary
The goal of this observational study is to learn about the long-term effects of Quantitative Flow Reserve (QFR) assessment in patients undergoing Coronary Artery Bypass Grafting (CABG). The main question it aims to answer is: Does preoperative QFR measurement improve graft outcomes and reduce major adverse cardiac and cerebrovascular events (MACE) in patients undergoing CABG? Participants who are scheduled for CABG and have undergone preoperative QFR assessment will be followed for one year post-surgery. They will provide data on graft patency and report any occurrences of MACE through regular follow-up visits and questionnaires about their health status.
Interventions
OTHERObservational
Observational study
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 to 80 years. * Patients whose angina pectoris significantly affects daily life and work, and for whom conservative medical treatment is ineffective, requiring coronary artery bypass grafting (CABG). * Preoperative coronary angiography data are available for quantitative flow ratio (QFR) analysis. * Patients with severe stenosis, defined as greater than 70% stenosis, in the three main coronary artery branches, including the left anterior descending artery, circumflex artery, and right coronary artery, with or without left main coronary artery stenosis greater than 50%.
Exclusion criteria
* Patients who cannot tolerate CABG due to comorbidities or complications. * Patients requiring urgent CABG or percutaneous coronary intervention (PCI). * Patients with significant congestive heart failure or hemodynamic instability. * Patients with a history of previous CABG or PCI within the past 6 months. * Patients who have experienced a stroke within the past 6 months. * Patients requiring concurrent cardiac procedures, such as valve surgery, maze surgery, radiofrequency ablation, or pacemaker implantation. * Patients with allergies to contrast agents or antiplatelet medications, or with contraindications to antiplatelet medications due to bleeding risks. * Patients with a significant history of bleeding, marked leukopenia, neutropenia, thrombocytopenia, anemia, or bleeding diathesis. * Patients currently participating in other prospective clinical studies. * Patients who are unwilling to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The patency of the graft vessels one year postoperatively. | 12 months | The patency of the radial artery graft in subjects who underwent coronary artery bypass grafting (CABG) one year postoperatively was assessed using coronary computed tomography angiography (CCTA) or conventional angiography (CAG), and its functional status was evaluated. Patency was classified according to the FitzGibbon classification system: Grade A indicates widely patent grafts, Grade B indicates grafts with limited flow (stenosis \< 50%), Grade S denotes the presence of string sign (stenosis \> 50% at any location of the graft), and Grade O signifies graft occlusion. Grades S and O were considered indicative of graft failure. The angiographic/CTA evaluations were conducted by two clinical physicians who were blinded to the preoperative quantitative flow ratio (QFR) values. |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of major adverse cardiovascular and cerebrovascular events (MACCE) at one year post-surgery, including all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, and repeat revascularization. | 12 months |
Countries
China
Contacts
CONTACTTong Ding, MD
Outcome results
None listed