Hypertension
Conditions
Brief summary
This study focuses on the specificity of thermosensitive targets in populations with hypertension in cold regions, identifies core targets through transcriptome sequencing and clinical validation, and clarifies the regulatory mechanism of moderate-intensity aerobic exercise through a prospective cohort study, providing scientific basis for precise prevention and treatment of hypertension in cold regions and personalized exercise intervention.
Interventions
BEHAVIORALExercise exposure
Patients with essential hypertension in cold regions who met the inclusion criteria were prospectively recruited and divided into an exercise exposure group and a non-exercise control group based on their willingness to accept and adhere to the exercise protocol developed for this study, with a follow-up period of 16 weeks. At baseline and the end of follow-up, we measured the expression of core thermosensitive targets, blood pressure (BP), heart rate variability (HRV), as well as the levels of sympathetic neurotransmitters and indicators of the renin-angiotensin-aldosterone system (RAAS), and compared the changes in these indicators between the two groups.
Sponsors
Wang Jingfeng
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 69 Years
Healthy volunteers
No
Inclusion criteria
* Same as the inclusion criteria for cold region hypertensive patients in the first stage; No regular moderate-intensity aerobic exercise in the past 3 months (≥3 times per week, ≥30 minutes per session); Exercise risk assessment is low to moderate risk (negative PAR-Q+ questionnaire); Voluntarily participate in this study and sign informed consent.
Exclusion criteria
* Same as the
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure (BP) | December 28, 2025 | Systolic blood pressure, unit: mmHg Diastolic blood pressure, unit: mmHg Mean arterial pressure, unit: mmHg |
| heart rate variability (HRV) | 28 December 2025 | Low Frequency，Unit: nu High Frequency ，Unit: nu Low Frequency / High Frequency ratio Root Mean Square of Successive Differences，Unit: ms Percentage of successive NN intervals differing by more than 50 ms，Unit: % Standard Deviation of all Normal-to-Normal RR intervals，Unit: ms |
| markers of the sympathetic nervous system (SNS) | December 28, 2025 | Epinephrine, unit: ng/L Norepinephrine, unit: ng/L |
| mRNA expression of genes | December 28, 2025 | Unit: relative expression level |
Countries
China
Outcome results
None listed