Hyperuricemia, Oxidative Stress, Periodontal Diseases
Conditions
Keywords
periodontal disease, hyperuricemia, oxidative stress, alveolar bone loss, inflammation
Brief summary
Periodontitis is a multifactorial disease characterized by chronic inflammation of the gum tissue and alveolar bone destruction, and is known to be associated with various systemic diseases. Hyperuricemia, on the other hand, is a metabolic condition characterized by increased serum uric acid levels and can affect inflammation, oxidative stress, and bone metabolism. In recent years, the relationship between hyperuricemia and periodontal diseases has been increasingly investigated, but the biological mechanisms of this relationship have not yet been fully elucidated. Therefore, this study aimed to determine whether there is a relationship between hyperuricemia and periodontitis and to reveal the possible pathophysiological mechanisms of this relationship, which are shaped by inflammation, oxidative stress, and bone metabolism. A total of 80 individuals aged 18-65 years will be included in this clinical observational study. The periodontal status of the participants will be assessed using clinical periodontal parameters such as probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing. Participants will be divided into four groups according to their periodontal status and the presence of hyperuricemia: individuals with periodontitis and hyperuricemia, individuals with periodontally healthy and hyperuricemia, individuals with periodontitis but without hyperuricemia, and individuals with periodontally healthy and without hyperuricemia. Gingival crevicular fluid and serum samples will be taken from the participants. In these samples, receptor-mediated nuclear factor kappa B ligand, osteoprotegerin, total antioxidant status, total oxidant status, oxidative stress index, interleukin-1 beta, interleukin-10, interleukin-18, and nucleotide-binding oligomerization domain-like receptor protein 3 levels will be analyzed. This study is considered unique because it examines the relationship between hyperuricemia and periodontitis by evaluating inflammation, oxidative stress, and bone metabolism parameters together.
Interventions
OTHERCollection of gingival crevicular fluid (GCF) and serum samples
Serum and GCF samples will be collected from participants in the first session
Periodontal clinical parameters will be measured from participants initially
Sponsors
Recep Tayyip Erdogan University Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Being between 18 and 65 years of age * Being systemically healthy or diagnosed with hyperuricemia * Having at least 20 natural teeth * Being periodontally healthy or diagnosed with periodontitis
Exclusion criteria
* Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism. * Smoking * Pregnancy or lactation * Having received periodontal treatment within the last 3-6 months * Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs * Presence of systemic diseases that may affect purine metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Periodontal pocket depth | at baseline | The distance between the gingival margin and the base of the pocket will be measured in millimeters. |
| clinical attachment loss | at baseline | The distance between the enamel-cementum junction and the base of the pocket will be measured in millimeters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of interleukin-1 beta | at baseline | Interleukin-1 beta levels will be determined from gingival crevicular fluid and serum samples using the ELISA method. |
| Level of interleukin-10 | at baseline | Interleukin-10 levels will be determined from gingival crevicular fluid and serum samples using the ELISA method. |
| Level of interleukin-18 | at baseline | Interleukin-18 levels will be determined from gingival crevicular fluid and serum samples using the ELISA method. |
Countries
Turkey (Türkiye)
Contacts
CONTACTHatice Yemenoglu
Outcome results
None listed