Healthy
Conditions
Brief summary
This pilot study evaluated whether a propolis-based topical solution improves soft-tissue healing after tooth extraction. Thirteen patients requiring extraction of two comparable teeth on opposite sides of the mouth were enrolled in a split-mouth design, in which one extraction site received the propolis solution while the other served as an internal control. The test site was treated with the propolis solution three times daily for seven days, while the control site received only saline rinses. Healing was tracked using 3D intraoral scans obtained before extraction and on days 7 and 14 afterward, allowing the percentage of socket closure to be measured objectively over time. Postoperative pain was also assessed using a standard visual pain scale on days 1, 3, and 7. The study aimed to determine whether this propolis-based formulation could serve as a natural, low-cost adjunct to standard post-extraction care to support faster tissue repair.
Interventions
DRUGPropolis-based topical solution (52% propolis extract, clove oil [Eugenia caryophyllus], and white willow bark [Salix alba] extract)
Drug: Propolis-Based Solution "A topical solution (52% propolis extract, clove oil, and white willow bark extract) applied to the test extraction socket via brush applicator three times daily for seven days."
OTHERSaline rinse (control)
The contralateral extraction socket received saline mouthwash only, with no active therapeutic agent applied, following the same pre-application oral hygiene steps (tooth brushing and saline rinse) as the test site
Sponsors
Saint-Joseph University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Split-mouth design
Eligibility
Sex/Gender
ALL
Age
8 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Cooperative adult patients willing to accept the study protocol * Minors with a cooperative parent/legal guardian providing consent * Non-surgical extraction of bilaterally positioned teeth * Low-to-moderate extraction difficulty per the Pederson scale * Systemically healthy, with no history of systemic disease
Exclusion criteria
* Non-consenting patients * Failure to attend follow-up appointments per protocol * Heavy smokers (\>10 pack-years) * Systemic disease (e.g., diabetes mellitus, immunosuppressive syndromes) * Current use of contraceptive medication * Systemic antibiotic therapy within the previous 3 months * Anticoagulant therapy within the previous 4 weeks * Requirement for antibiotic prophylaxis * Pregnant or breastfeeding women * Known allergy to honey or bee-related products * Known allergy to local anesthetics used in dental procedures * Higher-difficulty extractions requiring sutures or other hemostatic measures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of Extraction Socket Surface Area Closure | Baseline (Day 0), Day 7, and Day 14 post-extraction | Percentage reduction in socket surface area from baseline, calculated from 3D intraoral scans using the formula: % Closure = (Baseline area - Timepoint area) / Baseline area × 100. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Pain Score | Day 1, Day 3, and Day 7 post-extraction | Pain intensity rated on a 10-cm Visual Analog Scale (VAS), with higher scores indicating greater pain. |
Countries
Lebanon
Outcome results
None listed