Shivering Caused by Spinal Anesthesia
Conditions
Keywords
spinal anesthesia, phenylephrine, cesarean section, hypotension, shivering
Brief summary
This study aims to evaluate the effectiveness of continuous phenylephrine infusion at 50 mcg/min in preventing shivering after spinal anesthesia in cesarean section. This study was an open-label randomized clinical trial involving patients undergoing cesarean section under spinal anesthesia. Subjects were allocated into two groups: without phenylephrine and continuous phenylephrine infusion at 50 mcg/min. The primary outcome was the incidence of shivering during observation, assessed using the Crossley and Mahajan scale. Secondary outcomes included hypotension, ephedrine requirement, hemodynamic adverse events, and nausea vomiting.
Interventions
DRUGPhenylephrine
giving phenylephrine continous infusion at rate 50 mcg/minutes intravenously after insertion of spinal anesthesia
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Females aged 18-50 years. * Patients undergoing a Cesarean section procedure under spinal anesthesia. * Patients who are not in labor (non-labor). * Patients willing to participate in this study.
Exclusion criteria
* Patients with contraindications to phenylephrine. * Patients with allergies to the study medications. * Presence of fever (temperature \>37.5°C) or hypothermia (temperature \<35°C). * American Society of Anesthesiologists (ASA) score of III or higher. * Patients with a history of untreated thyroid disease. * Patients with a history of autonomic nervous system neuropathy. * Hypertension in pregnancy (or gestational hypertension). * Body Mass Index (BMI) greater than 35 kg/m².
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Shivering | after the moment of spinal anesthesia until end of surgery | incidence of shivering after spinal anestesia intraoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypotension | after the moment of spinal anesthesia until end of surgery | incidence of hypotension after spinal anesthesia, define as decreasing of more than 20% of blood pressure from baseline |
Countries
Indonesia
Outcome results
None listed