Cannabis Use, Opioid Use Disorders
Conditions
Keywords
Cannabis, marijuana, opioid, opioid use disorder, opioid withdrawal, opioid interaction
Brief summary
This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks. During this time, we will examine how repeated doses of oral cannabis and acute doses of oral and inhaled cannabis 1) modify the intensity and time course of opioid withdrawal, 2) modify the effects of intranasal opioid administration and 3) impact the safety of opioid administration.
Interventions
DRUGInhaled Cannabis
Participants will receive inhaled cannabis and placebo
DRUGIntranasal Opioid
Participants will receive intranasal opioids and placebo
Sponsors
University of Kentucky
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Participants with moderate to severe opioid use disorder
Exclusion criteria
* Individuals who do not use opioids or do not experience opioid withdrawal when they stop using opioids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Opioid withdrawal severity | This outcome will be assessed regularly from baseline through 6 hours post cannabis dose during experimental sessions. | Opioid severity is a participant-rated outcome that will be measured on a visual analog scale (0-100) |
Countries
United States
Contacts
CONTACTPaul Nuzzo
PRINCIPAL_INVESTIGATORShanna Babalonis, PhD
University of Kentucky College of Medicine
Outcome results
None listed