Osteoporosis, Vertebral Fractures, Vitamin C Deficiency
Conditions
Brief summary
This monocentric observational study aims to evaluate the association between plasma vitamin C levels (ascorbemia) and the presence of osteoporotic vertebral fractures in patients with osteoporosis. Forty participants will be enrolled at the Rheumatology
Detailed description
1. . Patients in group A or B will be seen in consultation or admitted by one of the medical team members among the investigators. 2. . After signing the informed consent and checking the inclusion criteria, the blood sample will be taken by a member of the nursing team of the department. 3. . The collection tube will then be placed in an opaque cooler, refrigerated with ice, and transported to the university hospital's biochemistry lab (routine assay). 4. . Next, the collection of planned clinical and paraclinical data: * Diet and risk factors for vitamin C deficiency: * Demographic data - osteoporosis risk factors * Bone status 5. . Once all the data is collected, we will carry out the statistical analyses, then draft the article, and finally publish it.
Interventions
DIAGNOSTIC_TESTPlasma vitamin C assessment
Blood sampling for measurement of plasma vitamin C concentration (ascorbemia) in patient of the study
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men aged 50 yars or older ; * Postmenopausal women ; * Afilliated with a health insurance and system ; * Written informed consent obtained. * Group 1 : Clincal osteoporotic vertebral fracture confirmed by imaging within the previous month ; Followed in the Rheumatology department for management of vertebral fracture. * Group 2 : Densitometric osteoporosis (T-score ≤ -2.5) ; No history of severe osteoporotic fracture ; No history of clinical or morphometric vertebral fracture.
Exclusion criteria
* Legal protection measure (guardianship, curatorship); * inability to provide informed consent ; * refusal to participate ; * Vertebral fracture related to tumor, * infection, trauma or non osteoporotic causes ; * asymptomatic vertebral fracture discovered incidentally ; * Severe densitometric osteoporosis for group 2 ; * Previous severe osteoporotic fracture for group B.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma vitamin C concentration | day 1 | Comparison of plasma vitamin C concentration (ascorbemia, µmol/L) between patients with osteoporotic vertebral fractures and patients with osteoporosis without vertebral fracture. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between plasma vitamin C level and number of vertebral fractures | day 1 | Assessment of the relationship between plasma vitamin C concentration and the number of osteoporotic vertebral fractures |
| Association between plasma vitamin C level and lumbar bone mineral density | day 1 | Assessment of the relationship between plasma vitamin C concentration and lumbar spine bone mineral density measured by DXA. |
Countries
France
Contacts
CONTACTMarie-charlotte Trojani, Doctor
Outcome results
None listed