Cerebral Autoregulation, General Anesthesia, Infant, Newborn, Near-infrared Spectroscopy
Conditions
Brief summary
This prospective observational study aims to determine the blood pressure range in which cerebral autoregulation is maintained in preterm neonates, preterm infants, term neonates, and term infants undergoing non-cardiac surgery under general anesthesia. Cerebral autoregulation will be assessed using the cerebral oximetry index, calculated from mean arterial pressure and regional cerebral oxygen saturation measured by near-infrared spectroscopy. A total of 160 patients, 40 in each age group, will be enrolled. The lower limit of autoregulation, optimal mean arterial pressure, and upper limit of autoregulation will be estimated for each patient and compared across age groups. The results may help support age-specific intraoperative blood pressure management in vulnerable pediatric patients.
Interventions
None listed
Sponsors
Seoul National University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Days to 12 Months
Healthy volunteers
No
Inclusion criteria
Pediatric patients undergoing non-cardiac surgery under general anesthesia Expected duration of anesthesia of 60 minutes or longer Patients who meet one of the following age criteria: Preterm neonates: born at \<37 weeks of gestation and ≤1 month of postnatal age Preterm infants: born at \<37 weeks of gestation and 1-12 months of postnatal age Term neonates: born at ≥37 weeks of gestation and ≤1 month of postnatal age Term infants: born at ≥37 weeks of gestation and 1-12 months of postnatal age Written informed consent obtained from a parent or legal guardian
Exclusion criteria
* Presence of residual congenital heart disease * Undergoing cardiac surgery * Undergoing neurosurgery * Presence of severe brain malformation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure limits of cerebral autoregulation | From the start of cerebral oxygen saturation monitoring after arrival in the operating room until the end of general anesthesia, approximately 1 to 6 hours. |
Countries
South Korea
Outcome results
None listed