Overweight , Obesity, Poly Cystic Ovary Syndrome
Conditions
Keywords
polycystic ovary syndrome, women, cardiometabolic, Physical activity
Brief summary
The primary objective of this study is to investigate the effects of a multidisciplinary intervention, including a targeted adapted physical activity program, on lipid oxidation during a walking exercise in women with overweight or obesity, with or without polycystic ovary syndrome. Specifically, the study aims to compare changes in lipid oxidation before and after the intervention between women with polycystic ovary syndrome and those without polycystic ovary syndrome. The secondary objectives are to assess the impact of polycystic ovary syndrome on several physiological and metabolic parameters in women with overweight or obesity. These include: (i) resting energy metabolism; (ii) resting blood pressure and heart rate; (iii) energy expenditure, energy cost, and heart rate during a walking exercise; (iv) body composition, glycemic and lipid profiles, and circulating levels of sex hormones and adipokines; (v) movement behaviors; and (vi) physical fitness. In addition, the effect of the multidisciplinary intervention, including the adapted physical activity program, will be evaluated on these same outcomes: (i) resting energy metabolism; (ii) resting blood pressure and heart rate; (iii) energy expenditure, energy cost, and heart rate during walking exercise; (iv) body composition, glycemic and lipid profiles, and concentrations of sex hormones and adipokines; (v) movement behaviors; and (vi) physical fitness, in women with overweight or obesity, with or without polycystic ovary syndrome.
Interventions
BEHAVIORALPhysical activity
Participants will participate to adapted physical activity, supervised by a professional
Sponsors
University Hospital, Clermont-Ferrand
SMR Nutrition Obésité UGECAM
Laboratoire AME2P
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
The participants will have different conditions, with or without polycystic ovary syndrome, but will follow the same intervention
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Women aged 18 to 40 years (inclusive boundaries) * Women with a body mass index (BMI) between 25 and 40 kg/m² * Women performing no more than 150 minutes of moderate-to-vigorous physical activity per week * Women able to provide informed consent to participate * Women affiliated with a social security system * One group will consist of women with polycystic ovary syndrome, and another group will consist of women without polycystic ovary syndrome
Exclusion criteria
* Pregnancy or breastfeeding, as declared by the participant * Postmenopausal women * Women currently receiving pharmacological treatment for obesity or who have received such treatment within the past two years * Women under legal protection measures (guardianship, curatorship, or judicial protection) * Refusal to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid oxidation during walking exercise | Baseline and after 10 weeks of intervention |
Secondary
| Measure | Time frame |
|---|---|
| Energy expenditure at rest | Baseline and after 10 weeks of intervention |
| Lipid oxidation at rest | Baseline and after 10 weeks of intervention |
| Carbohydrate oxidation at rest | Baseline and after 10 weeks of intervention |
| Systolic blood pressure at rest | Baseline and after 10 weeks of intervention |
| Diastolic blood pressure at rest | Baseline and after 10 weeks of intervention |
| Heart rate at rest | Baseline and after 10 weeks of intervention |
| Energy expenditure during walking exercise | Baseline and after 10 weeks of intervention |
| Energy cost of walking | Baseline and after 10 weeks of intervention |
| Carbohydrate oxidation during walking exercise | Baseline and after 10 weeks of intervention |
| Heart rate during walking exercise | Baseline and after 10 weeks of intervention |
| Fat mass | Baseline and after 10 weeks of intervention |
| Fat-free mass | Baseline and after 10 weeks of intervention |
| Body hydration | Baseline and after 10 weeks of intervention |
| Fasting glycemia | Baseline and after 10 weeks of intervention |
| Fasting insulin concentrations | Baseline and after 10 weeks of intervention |
| Fasting triglyceride concentrations | Baseline and after 10 weeks of intervention |
| Fasting LDL cholesterol concentrations | Baseline and after 10 weeks of intervention |
| Fasting HDL concentrations | Baseline and after 10 weeks of intervention |
| Fasting total cholesterol concentrations | Baseline and after 10 weeks of intervention |
| Fasting free-fatty acid concentrations | Baseline and after 10 weeks of intervention |
| Follicle-stimulating hormone concentrations | Baseline and after 10 weeks of intervention |
| Luteinizing hormone concentrations | Baseline and after 10 weeks of intervention |
| Estrogen concentrations | Baseline and after 10 weeks of intervention |
| Progesterone concentrations | Baseline and after 10 weeks of intervention |
| Total testosterone concentrations | Baseline and after 10 weeks of intervention |
| Free testosterone concentrations | Baseline and after 10 weeks of intervention |
| Fasting leptin concentrations | Baseline and after 10 weeks of intervention |
| Fasting adiponectin concentrations | Baseline and after 10 weeks of intervention |
| Time spent in sedentary behaviors | Baseline and after 10 weeks of intervention |
| Time spent in moderate-to-vigorous physical activity | Baseline and after 10 weeks of intervention |
| Physical fitness-minute walking distance | Baseline and after 10 weeks of intervention |
| Right hand grip strength | Baseline and after 10 weeks of intervention |
| Left hand grip strength | Baseline and after 10 weeks of intervention |
| Number of repetitions during the 30-seconde chair stand test | Baseline and after 10 weeks of intervention |
| Herat rate at the end of the step test | Baseline and after 10 weeks of intervention |
| Heart rate 1 minute after the end of the step test | Baseline and after 10 weeks of intervention |
| Heart rate 2 minutes after the end of the step test | Baseline and after 10 weeks of intervention |
| Heart rate 3 minutes at the end of the step test | Baseline and after 10 weeks of intervention |
Countries
France
Contacts
CONTACTLise Laclautre
Outcome results
None listed