Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease

Association Between Modifiable Risk Factors and Cognitive Function in Patients With Coronary Heart Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07657624

Enrollment

2352

Registered

2026-06-18

Start date

2025-06-30

Completion date

2031-05-01

Last updated

2026-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Mild, Coronary Heart Disease

Keywords

Risk Factors, Cognitive Impairment, Coronary Heart Disease

Brief summary

This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.This study is led by the National Clinical Research Center for Cardiovascular Diseases and invited to be carried out by several Chinese centers including Beijing Anzhen Hospital.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age ≥ 18 years 2. Diagnosis of coronary heart disease (meeting at least one of the following): * Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery; * Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment; * Objective evidence of myocardial ischemia or typical clinical symptoms 3. Completion of standardized neuropsychological assessment during hospitalization 4. Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments 5. Provision of signed written informed consent

Exclusion criteria

1. Previously diagnosed dementia. 2. History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment. 3. Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder). 4. Pregnancy or breastfeeding.

Design outcomes

Primary

Measure	Time frame	Description
Cognitive impairment	2026-2031	Cognitive impairment in patients with coronary heart disease, defined by standardized neuropsychological assessments including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Brief Cognitive Assessment Tool (BCAT), and Alzheimer's Disease 8-Item Screening Questionnaire (AD8), evaluated as a binary outcome (presence or absence of cognitive impairment).

Countries

China

Contacts

CONTACTChenchen Tu, Chief Physician

tcc2033@163.com15201648899

Outcome results