Chronic Kidney Disease, Diabetes
Conditions
Keywords
Diabetes; Weight Reduction; Oxidative Stress; Cytokines; Obesity.
Brief summary
This research intends to analyze how a 12-week adjustment in lifestyle influences inflammatory cytokines and oxidative stress indicators in overweight individuals diagnosed with type 2 diabetes and moderate CKD
Detailed description
: 60 patients, mostly sedentary, aged 36-58 years, were diagnosed with stages 3 and 4 chronic kidney disease (eGFR 25 to 60 ml/min/1.73 m²) with concomitant type 2 diabetes and indicated body mass indexes (BMI) between 30 to 35 kg/m². The subjects were randomly assigned to two unique groups: Intervention group (Group A): Participants completed supervised aerobic treadmill exercises while sticking to a calorie-limited diet (1200 kcal/day) throughout a 12-week period. Control group (Group B): Participants received standard nephrology care without any alterations in lifestyle. In the initial phases, there was a detailed analysis of biomarkers which was later confirmed in a review conducted at the 12-week mark focusing on TNF-α, IL-6, sCRP, CD, MDA, GSH, GPx, and SOD.
Interventions
OTHERaerobic treadmill exercises
diet (1200 kcal/day)
Sponsors
Badr University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
36 Years to 58 Years
Healthy volunteers
No
Inclusion criteria
* sedentary lifestyle for at least three months prior to enrollment * body mass index (BMI) of 30-35 kg/m².
Exclusion criteria
* using tobacco * heart failure * coronary arteries * severe heart valve problems * pregnant * liver inflammation * kidney transplant * physical injuries restricting them from exercising * utilization of anti-inflammatory medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MDA | at baseline and after 12 WEEKS | malondialdehyde |
| GSH | at baseline and after 12 WEEKS | Glutathione |
| GPx | at baseline and after 12 WEEKS | Glutathione peroxidase |
| SOD | at baseline and after 12 WEEKS | Superoxide dismutase |
| IL-6 | at baseline and after 12 WEEKS | Interleukin-6 |
| TNF-α | at baseline and after 12 WEEKS | tumor necrosis factor alpha |
| CRP | at baseline and after 12 WEEKS | C-reactive protein |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BMI | at baseline and after 12 WEEKS | Body mass index |
Countries
Egypt
Contacts
CONTACTMona Mohamed Abdelkhalek, assistance professor
PRINCIPAL_INVESTIGATORMona Mohamed Abdelkhalek
Badr University
Outcome results
None listed