Ventilator Dependency
Conditions
Keywords
Ventilator Dependence, Chronic Disease, Mechanical Ventilation, Intensive Care Units, Risk Factors, Digital Phenotyping
Brief summary
This project plans to employ a multi-center retrospective and prospective cohort study design. It aims to collect data on ventilator support strategies, duration of invasive mechanical ventilation, incidence of ventilator dependence, high-risk factors for ventilator dependence, and in-hospital mortality rates among different chronic disease populations in the ICU. This will involve combining unstructured data with real-time bedside multi-dimensional high-frequency data (including dynamic changes in data volume, respiratory mechanics, diaphragm ultrasound, EIT, diaphragm electrical activity, and other monitoring parameters) to construct digital phenotypes for chronic disease patients with ventilator dependence and identify high-risk factors for ventilator dependence in this population. Specifically, the research will: Utilize an integrated modular intelligent respiratory monitoring system, previously developed by the project team, to achieve dynamic monitoring of multi-dimensional indicators. Systematically collect dynamic clinical characteristics of mechanical ventilation dependence in chronic disease populations through retrospective and prospective cohort studies, and employ multivariate statistical analysis, machine learning, and other techniques to identify no fewer than 5-6 high-risk factors for ventilator dependence in chronic disease patients. Establish a data ecosystem suitable for chronic disease patients undergoing mechanical ventilation, build a multi-dimensional high-frequency data platform for chronic ventilator-dependent populations, map the full cycle from intubation to mechanical ventilation support, weaning, and extubation, and construct multidimensional digital phenotypes for high-risk chronic disease patients with ventilator dependence.
Interventions
None listed
Sponsors
China-Japan Friendship Hospital
Zhongda Hospital
First Affiliated Hospital of Chongqing Medical University
Shenzhen Mindray Bio-Medical Electronics Co., Ltd
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years old. * Patients admitted to ICU and receiving invasive mechanical ventilation. * Comorbid with chronic diseases.
Exclusion criteria
* Total invasive mechanical ventilation duration ≤ 48 hours. * Death within 7 days after ICU admission. * Withdrawal of treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of ventilator dependence（mechanical ventilation time≥7 days） in chronic disease patients receiving invasive mechanical ventilation | From enrollment to 7 days | the proportion of patients who achieve sustained liberation from invasive mechanical ventilation within 7 days of the initial intubation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of chronic disease patients still receiving IPPV at 14/21 days after mechanical ventilation | 21 days | the proportion of patients who achieve sustained liberation from invasive mechanical ventilation within 14 and 21 days of the initial intubation. |
| Success rate of the first Spontaneous Breathing Trial (SBT) in chronic disease patients | during hospitalization，assessed up to 28 days | — |
| Time to first extubation in chronic disease patients | during hospitalization，assessed up to 28 days | — |
| Proportion of first extubation failure in chronic disease patients | during hospitalization，assessed up to 28 days | — |
| High-risk factors for first extubation failure in chronic disease patients | during hospitalization，assessed up to 28 days | — |
| ICU mortality rate | during hospitalization，assessed up to 28 days | — |
| In-hospital mortality rate | during hospitalization，assessed up to 28 days | — |
| ICU length of stay | during hospitalization，assessed up to 28 days | — |
| Total hospital length of stay | during hospitalization，assessed up to 28 days | — |
| Duration of invasive mechanical ventilation | during hospitalization，assessed up to 28 days | — |
| Incidence of Ventilator-Associated Pneumonia (VAP) | during hospitalization，assessed up to 28 days | — |
| Proportion of patients undergoing tracheostomy | during hospitalization，assessed up to 28 days | — |
| Time of tracheostomy | during hospitalization，assessed up to 28 days | among those who receive tracheostomy |
| High-risk factors for ventilator dependence in chronic disease patients | during hospitalization，assessed up to 28 days | — |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORXu Huang, MD
Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital
Outcome results
None listed