ERAS in Total Knee Arthroplasty: a Randomized Controlled Trial

Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols in Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Tria

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07655921

Acronym

ERAS

Enrollment

120

Registered

2026-06-18

Start date

2025-05-13

Completion date

2026-07-01

Last updated

2026-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ERAS, TKA

Brief summary

Total knee arthroplasty(TKA) is the most commonly performed procedure for advanced knee osteoarthritis. Enhanced recovery after surgery (ERAS) protocols are primarily implemented to reduce perioperative stress and improve surgical and functional outcomes. Evidence of the implementation of ERAS protocols in low to middle-income countries like Pakistan is limited. This study aims to evaluate the effectiveness of ERAS protocols in TKA patients. A prospective randomized controlled trial study was conducted within our institute from July 2025 to January 2026, in which a total of 239 patients who underwent primary bilateral TKA, of which 121 patients received conventional treatment and protocols, and a study group with 120 participants were managed according to the ERAS protocol. Patients were in the 50-70 years age bracket, and had an American Society of Anesthesiologists grade I-III. The protocol included preoperative physiotherapy, reduced fasting time, multimodal anesthesia, perioperative tranexamic acid, early ambulation and early oral intake. Postoperative outcomes included time to oral intake, postoperative nausea and vomiting, time to mobilization, length of hospital stay, range of motion and Hospital for Special Surgery score.

Interventions

BEHAVIORALERAS PROTOCOL

ERAS IMPLEMENTATION IN TKA PATIENTES

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA grade of 1-3 BMI was restricted to less than 30 kg/m²

Exclusion criteria

* ASA grade of IV or higher uncontrolled comorbidities not consenting to the protocol

Design outcomes

Primary

Measure	Time frame	Description
TIME TO ORAL INTAKE	Baseline	DURATION AFTER WHICH NPO WAS BROKEN
Length of hospital stay	through study completion, an average of 1 year	STAY IN THE HOSPITAL AFTER THE INTERVENTION

Countries

Pakistan

Contacts

CONTACTDR MOHAMMAD ZEESHAN HAIDER, MBBS

mohammadzh321@gmail.com+923432886821

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 19, 2026