Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07655596

Enrollment

100

Registered

2026-06-18

Start date

2026-07-01

Completion date

2026-12-31

Last updated

2026-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical Site Infection (SSI)

Keywords

cefazolin, orthopedic surgery

Brief summary

A randomized controlled trial on adults who underwent orthopedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in the orthopedic surgical population. Eligible patients will be randomized in a block design into 2 groups: intervention and control. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).

Interventions

DRUGCefazolin 2 g Infusion

Intraoperative continuous infusion (CI) of cefazolin

DRUGCefazolin 2 GM Injection

Administration of cefazolin 2 gm 30 minutes pre-surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Orthopaedic surgical ward patients who underwent major surgery.

Exclusion criteria

* Patients who require reoperation within 30 days. * Immunosuppressant patients. * Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively. * Pregnancy or breastfeeding.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of surgical site infection	within 90 days after surgery.	To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in the orthopedic surgical population.

Contacts

CONTACTHeba A Abdeen

hebabdeen89@gmail.com0201003403231

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 25, 2026