Isometric Hand-Grip Exercise for Preventing Thrombosis and Occlusion of Midline Venous Catheters: A Randomized Controlled Trial

Effectiveness of Isometric Hand-grip Exercise in Preventing Thrombosis and Occlusion of Midline Peripheral Venous Catheters: a Randomized Controlled Trial.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07654101

Enrollment

840

Registered

2026-06-17

Start date

2026-07-06

Completion date

2027-09-01

Last updated

2026-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Midline Catheter

Keywords

midline, occlusion, handgrip

Brief summary

evaluate whether hand-grip ball exercises reduce thrombosis and occlusions of Midline catheters in hospitalized patients.

Detailed description

The proposed intervention consists of low-intensity, short-duration, non-invasive, and non-pharmacological exercises, with an expected minimal risk profile. The aim of the study is therefore to systematically evaluate the effectiveness and safety of this practice in patients with Midline catheters, in a context of genuine scientific uncertainty, in order to generate evidence useful for clinical practice. Primary objective To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients. Associated endpoints Incidence of Midline thrombosis (%) confirmed by ultrasound.

Interventions

OTHERhandgrip

handgrip in patients with midline catethers

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Midline catheter insertion for planned intravenous therapy lasting ≥ 7 days. Age between 18 and 70 years. Catheter inserted in the upper limb (forearm). Ability to understand and perform hand exercises with the limb bearing the venous catheter. Written informed consent.

Exclusion criteria

* Pre-existing superficial or deep venous thrombosis of the limb used for the Midline catheter. Limb injuries or amputations. Motor or neurological impairment of the hand. Life expectancy \< 7 days. Cognitive impairment/delirium. Medical contraindications to active upper-limb movement.

Design outcomes

Primary

Measure	Time frame	Description
To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.	from enrollment until catether removal	Incidence of Midline thrombosis (%) confirmed by ultrasound.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 18, 2026