Left Atrial and Left Ventricular Structural and Functional Evaluation by CCTA for Predicting Post-Ablation Outcomes in Patients With Atrial Fibrillation

Using CCTA to Assess Heart Function and Predict AF Recurrence After Ablation

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07651046

Acronym

LAVE-AF

Enrollment

Registered

2026-06-16

Start date

2024-08-15

Completion date

2028-08-01

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation (AF)

Brief summary

This study aims to evaluate whether structural and functional parameters of the left atrium and left ventricle, measured by cardiac computed tomography angiography (CCTA), can predict clinical outcomes after radiofrequency ablation in patients with atrial fibrillation (AF). Atrial fibrillation is a common heart rhythm disorder, and while catheter ablation is an effective treatment, some patients experience recurrence. Current predictive tools have limitations. This prospective observational study will enroll patients with AF scheduled for first-time radiofrequency ablation. All participants will undergo CCTA before the ablation procedure to assess left atrial and left ventricular volumes, ejection fraction, and strain parameters. After ablation, patients will be followed for 12 months to monitor recurrence of atrial arrhythmias. The primary outcome is the recurrence of atrial fibrillation or atrial tachycardia lasting more than 30 seconds after a 3-month blanking period. The study will determine whether CCTA-derived parameters improve risk stratification for post-ablation recurrence. Findings may help identify patients who are more likely to benefit from ablation or who may need additional therapy.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Meet the indications for radiofrequency ablation recommended by relevant atrial fibrillation diagnosis and treatment guidelines 2. Age ≥ 18 years 3. First-time radiofrequency ablation

Exclusion criteria

1. history of cardiac ablation 2. structural heart diseases, such as cardiomyopathy, valvular disease, heart failure, and acute myocardial infarction 3. severe renal failure (estimated glomerular filtration rate \<30 ml/m2) 4. left ventricular (LV) ejection fraction \<30% 5. poor image quality inadequate for assessment

Design outcomes

Primary

Measure	Time frame	Description
Recurrence of atrial arrhythmia after ablation	12 months after ablation (following the initial 3-month blanking period)	Recurrence of atrial fibrillation, atrial flutter, or atrial tachycardia lasting 30 seconds or longer, documented by electrocardiogram (ECG) or Holter monitoring, after a 3-month blanking period following radiofrequency ablation.

Countries

China

Outcome results