Brain Tumor Adult, Glioma
Conditions
Keywords
Movie Functional Magnetic Resonance Imaging, Clinical Functional Magnetic Resonance Imaging, Presurgical Planning, Presurgical Brain Mapping
Brief summary
This research will compare a new type of functional MRI (fMRI) called naturalistic viewing (also called movie watching) to standard clinical fMRI techniques. Standard clinical fMRI currently uses multiple tasks such as reading and responding to words or sentences to determine which areas of the brain are responsible for language. Surgeons can use this information to help plan brain surgeries. This research will help determine if the movie-watching fMRI is equivalent or better than the standard task-based fMRI. If so, it could be useful for planning patients' surgeries in the future, without the need for multiple tasks.
Interventions
OTHERFunctional magnetic resonance imaging (fMRI)
Functional magnetic resonance imaging (fMRI) is a type of non-invasive imaging that measures blood oxygen level-dependent (BOLD) signal changes in the brain when a task is performed (such as reading) or BOLD signal changes during resting or watching naturalistic stimuli (such as movie clips).
BEHAVIORALNeuropsychological Assessments
Neuropsychological assessments are standardized tests used to evaluate cognitive, behavioral, and emotional functions that reflect the performance of different brain systems. These tests can be on paper or on a computer.
Sponsors
Brigham and Women's Hospital
National Institute on Deafness and Other Communication Disorders (NIDCD)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Any sex, age between 21 to 70 years; * Known or suspected glioma (lesion) of the brain; * English speaking; * Patients with clinical fMRI scheduled (or pending scheduling) for presurgical planning at BWH ordered by a BWH clinician; * Passes prescreening and standard of care screenings for 3 Tesla MRI; * Willing to participate in the additional study scan and neuropsychological assessment visit; * Informed consent form signed by the subject or legally acceptable representative.
Exclusion criteria
* Contraindications to MRI: Note: MRI screening will be performed by radiology staff as part of their standard process for their clinical scans and if subjects do not pass the screen, MRI will not be performed. * Pregnancy or possible pregnancy: Female participants under 55 (or 45 with menstrual cycle in the past 12 months) who may be pregnant. Per policy: potential subjects will be asked if they are pregnant and excluded if they say yes. If unsure, pregnancy testing will be performed. Any subjects with positive result will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Language localization | From enrollment to up to 6 months after brain surgery. | Sensitivity and specificity based on the proportion of activation within and outside of language regions-of-interest (ROIs). |
| Language lateralization | From enrollment to up to 6 months after brain surgery. | Laterality index (LI) based on proportion of activation in the left vs. right hemisphere in language regions-of-interest (ROIs). |
| FMRI language activations concordance with language fiber tracts | From enrollment to up to 6 months after brain surgery. | Concordance with language fiber tracts identified by diffusion MRI in terms of the Euclidean distance between fMRI language activations and the tracts. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality metrics based on electrocortical stimulation (ECS) | From enrollment to up to 6 months after brain surgery. | Sensitivity and specificity computed relative to ECS positive/negative areas. |
Countries
United States
Contacts
CONTACTYanmei Tie, PhD
CONTACTLaura Rigolo
PRINCIPAL_INVESTIGATORYanmei Tie, PhD
Brigham and Women's Hospital
Outcome results
None listed