Perioperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Clinical Study

Prospective Clinical Study for Evaluation of Perioperative Myocardial Injury Using High-Sensitivity Troponin and Cardiac MRI in Patients Undergoing Coronary Artery Bypass Grafting (CABG)

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07650487

Enrollment

150

Registered

2026-06-16

Start date

2026-07-01

Completion date

2027-07-30

Last updated

2026-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Myocardial Injury

Keywords

Perioperative Myocardial Injury, Coronary Artery Bypass Grafting, Cardiac MRI, hs-Troponin, Coronary Artery Disease

Brief summary

Perioperative myocardial injury (PMI) following coronary artery bypass grafting (CABG) is associated with postoperative morbidity, mortality, and long-term outcomes. High-sensitivity troponin assays and cardiac MRI offer reliable diagnostic tools for PMI, but evidence regarding optimal diagnostic thresholds and perioperative imaging strategy is limited. This prospective clinical study aims to determine the incidence of perioperative myocardial injury using multimodal assessments including high-sensitivity troponin, electrocardiogram, echocardiography, cardiac MRI, and perioperative cardiovascular events.

Interventions

DIAGNOSTIC_TESTHigh-Sensitivity Troponin

High-sensitivity troponin levels are measured preoperatively, predischarge, and at 6-month follow-up to assess perioperative myocardial injury.

DIAGNOSTIC_TESTCardiac MRI

A diagnostic assessment panel including high-sensitivity troponin testing, electrocardiography, echocardiography, and cardiac magnetic resonance imaging performed during the perioperative period.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Age ≥ 21 years 2. Undergoing CABG for unstable angina 3. Able to provide written informed consent 4. No major cardiovascular event in the prior 6 months

Exclusion criteria

1. Significant hepatic, renal, or other major organ dysfunction 2. Pregnancy or breastfeeding 3. Withdrawal during the study 4. Contraindication to cardiac MRI (metal implants, claustrophobia, etc.)

Design outcomes

Primary

Measure	Time frame	Description
Incidence of Perioperative Myocardial Injury (PMI)	Within 48 hours post-CABG	Perioperative myocardial injury defined by elevation of high-sensitivity troponin above the 99th percentile upper reference limit together with new myocardial injury detected by cardiac MRI or supportive ECG/echocardiographic changes. PMI is assessed using laboratory testing and imaging performed preoperatively, within 48 hours post-CABG, and at discharge.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 17, 2026