Pulmonary Hypertension Due to Lung Disease (Disorder)
Conditions
Keywords
Pulmonary Hypertension Cardiopulmonary Rehabilitation Inspiratory Muscle Training Exercise Training Functional Capacity Pulmonary Function
Brief summary
This study aims to investigate the effect of cardiopulmonary rehabilitation on cardiorespiratory parameters and functional capacity in patients with pulmonary hypertension.
Detailed description
Pulmonary hypertension is a progressive disease associated with reduced exercise capacity, respiratory muscle weakness, and impaired quality of life. Exercise training and respiratory muscle training have been shown to improve physical performance and quality of life in patients with pulmonary hypertension. forty-two medically stable patients with Group III pulmonary hypertension due to lung diseases (obstructive and restrictive) will participate in this comparative experimental study. Participants will receive cardiopulmonary rehabilitation consisting of moderate-intensity interval aerobic training and inspiratory muscle training in addition to routine medical treatment. Outcome measures will include echocardiographic parameters, pulmonary function, six-minute walk distance, estimated VO2max, dyspnea severity, and quality of life. The study aims to evaluate the influence of cardiopulmonary rehabilitation on cardiorespiratory adaptation in patients with pulmonary hypertension.
Interventions
BEHAVIORALcardiopulmonary rehabilitation in the form of moderate-intensity interval aerobic training
Training will be conducted on a treadmill three times weekly for 12 weeks. Exercise intensity will progress from 30-40% to 60-70% of target heart rate. Each session will last 30 minutes and include warm-up and cool-down periods.
DEVICEInspiratory Muscle Training
inspiratory muscle training will be performed using a Threshold Inspiratory Muscle Trainer (Philips Respironics). Training intensity will correspond to moderate-to-severe effort (3-5 on the Modified Borg Scale).
OTHERMedical treatment
medication
Sponsors
Cairo University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
\- a)Medically stable pulmonary hypertension patients who were under optimized medical therapy. b)Pulmonary artery pressure ≥ 25 mmHg confirmed by RT side heart catheterization. c)Forty two male patients with group 3 pulmonary hypertension (Chest cause) include Obstructive lung disease ( COPD and sleep apnea ) and restrictive lung disease (ILD). d)The patients' ages will range from 45 to 65 years old. e)BMI (25 - 34.9) kg/m2. f)World Health Organization (WHO) classification of functional classes II to III ( class II are patients with pulmonary hypertension who have a mild limitation of physical activity )(class III are patients with pulmonary hypertension who have a marked limitation of physical activity
Exclusion criteria
* g)Uncontrolled systemic HTN. h)Other types of pulmonary hypertension.. i)Smoker j)Any condition of kidney failure. k)Neurological or musculoskeletal conditions that interfere with gait l)Impaired vision and/or hearing. m)Patients who are unable to follow verbal instructions. n)acute exacerbation condition. o)unstable angina, serious cardiac dysrhythmias on resting ECG.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 6-minute walk distance | 12 weeks | total distance walked in 6 minutes |
| Maximal Oxygen Consumption | 12weeks | Estimated VO2max |
| spirometry | 12weeks | FEV1, FVC, FEV1/FVC, MVV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dyspnea Severity | 12weeks | Modified Borg Scale |
| change Pulmonary Artery Pressure | 12weeks | pulmonary artery pressure estimated by ECHO |
| change of total score of SF-12 Questionnaire) Quality of Life | 12weeks | more increase scores more increase quality of life |
Countries
Egypt
Contacts
CONTACTRana Essam El Din Abd Elbar, Assistant lecturer
STUDY_CHAIRNESREEN GHAREEB MOHAMED EL-NAHAS, Prof PT
faculty of P.T. Cairo University
STUDY_CHAIRHEBA AHMED ALI ABDEEN, Prof
faculty of P.T. Cairo University
STUDY_CHAIRHEND ABD EL-MONAEM ABD EL-MONAEM, Lecturer of physical therapy
faculty of P.T. Cairo University
STUDY_CHAIRREEM IBRAHIM EL KORASHY, prof of pulmonology
Cairo University
Outcome results
None listed