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Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical Study

EVALUATION OF DIFFERENT NON-INVASIVE METHODS IN THE TREATMENT OF DENTIN HYPERSENSITIVITY ASSOCIATED WITH NON-CARIOUS CERVICAL LESIONS: A SPLIT-MOUTH CLINICAL STUDY

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07648147
Acronym
NCCL-DH
Enrollment
30
Registered
2026-06-15
Start date
2026-07-20
Completion date
2027-01-20
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Hypersensitivity, Non-Carious Cervical Lesions (NCCLs)

Keywords

Non-Carious Cervical Lesions; Dentin Hypersensitivity; Diode Laser; D Blue Diode Laser; Bioactive Glass; ProSylc; Split-Mouth Study; Non-Invasive Treatment

Brief summary

The aim of this split-mouth clinical study is to compare the effectiveness of D Blue diode laser application and ProSylc bioactive glass powder application in reducing dentin hypersensitivity in patients with non-carious cervical lesions (NCCLs). Different treatment modalities will be applied within the same participant, and changes in dentin hypersensitivity will be evaluated following treatment. The primary outcome measure will be the reduction in dentin hypersensitivity after the interventions. The findings of this study are expected to contribute to the identification of effective non-invasive treatment approaches for the management of dentin hypersensitivity associated with non-carious cervical lesions.

Detailed description

This split-mouth clinical study was designed to compare the clinical effectiveness of two different non-invasive approaches used in the treatment of dentin hypersensitivity associated with non-carious cervical lesions (NCCLs). Dentin hypersensitivity is a common clinical condition characterized by a short, sharp pain arising from exposed dentin in response to thermal, evaporative, tactile, osmotic, or chemical stimuli. Non-carious cervical lesions play a significant role in the development of dentin hypersensitivity by exposing dentin surfaces to the oral environment. In this study, the effectiveness of D Blue diode laser application and ProSylc bioactive glass powder application in reducing dentin hypersensitivity will be evaluated. The split-mouth study design will allow each participant to serve as their own control, thereby minimizing interindividual variability. Eligible teeth will be allocated to different treatment groups according to the study protocol, and all interventions will be performed following standardized clinical procedures. The level of dentin hypersensitivity will be assessed before treatment and at predetermined follow-up intervals using standardized clinical evaluation methods. Based on the collected data, the effects of both treatment modalities on dentin hypersensitivity will be compared, and changes over time will be analyzed. In addition, the clinical applicability and patient tolerance of the interventions will be evaluated. The findings of this study are expected to contribute to the existing literature regarding the effectiveness of non-invasive treatment methods for dentin hypersensitivity associated with non-carious cervical lesions and to provide evidence-based guidance for clinicians in selecting appropriate treatment approaches.

Interventions

DEVICED Blue Diode Laser

D Blue diode laser application for the treatment of dentin hypersensitivity associated with non-carious cervical lesions.

DEVICEProSylc Bioactive Glass Powder

ProSylc bioactive glass powder application for the treatment of dentin hypersensitivity associated with non-carious cervical lesions.

Sponsors

Cukurova University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

This study will employ a split-mouth design in which each participant will receive both interventions on different eligible teeth. One side will be treated with D Blue diode laser, while the contralateral side will receive ProSylc bioactive glass powder application. This design allows direct comparison of treatment outcomes within the same individual and minimizes inter-individual variability.

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Individuals aged between 18 and 65 years. Systemically healthy individuals. Individuals with dentin hypersensitivity. Presence of two permanent teeth with similar severity of dentin hypersensitivity in the same participant. Participants who agree to participate in the study and sign the informed consent form

Exclusion criteria

* Presence of active caries in the study teeth. Presence of cervical restoration in the study teeth. Presence of pulpal pathology. History of desensitizing treatment within the last 3 months. Pregnancy. Presence of systemic disease. Use of analgesics within the last 48 hours.

Design outcomes

Primary

MeasureTime frameDescription
Change in Dentin HypersensitivityBaseline, immediately after treatment, 1 week, 1 month, and 3 monthsDentin hypersensitivity will be assessed using a Visual Analog Scale (VAS) following standardized air stimulus application. The change in VAS scores from baseline to follow-up visits will be evaluated.

Countries

Turkey (Türkiye)

Contacts

CONTACTHüsna Selinay S Dağdelen, Doctor of Dental Medicine
selinay428@gmail.com+905453051080
CONTACTEzgi S Sonkaya Akburak, Associate Professor Doctor
sonkayaezgi@yahoo.com+905054974631

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 16, 2026