Lacrifill for Ocular Surface Optimization in Cataract Surgery

Evaluation of Lacrifill™ Canalicular Filler for Optimization of Ocular Surface Parameters and Biometric Precision in Prospective Cataract Surgery Patients With Dry Eye Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07648095

Enrollment

Registered

2026-06-15

Start date

2026-07-22

Completion date

2027-07-15

Last updated

2026-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract

Brief summary

This is a single-site observational study designed to evaluate the efficacy of Lacrifill™ canalicular filler in optimizing ocular surface parameters and biometric precision in prospective cataract surgery patients with dry eye disease (DED).

Interventions

DEVICELacrifill Canalicular Filler

Lacrifill Canalicular Filler

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>= 40 years * Diagnosed dry eye (OSDI \>= 13, TBUT \< 10 sec, or Oxford staining \>= Grade 2) * No recent ocular surgeries (\<6 months) * No significant changes in DED regimen within last 1 month

Exclusion criteria

* Previous punctal plugs or canalicular cautery * Active ocular inflammation or corneal pathology unrelated to DED

Design outcomes

Primary

Measure	Time frame	Description
Mean absolute error (MAE)	1 month postoperatively	Difference in mean spherical equivalent Mean Absolute Error (MAE) between actual postoperative manifest refraction spherical equivalent and back-calculated equivalent based on baseline biometry.

Secondary

Measure	Time frame	Description
Difference in mean magnitude of postoperative refractive astigmatism	1 month postoperatively	—
Lens type candidacy	Preoperative assessment	Evaluation of patient eligibility for IOL based on improved ocular surface conditions and investigator medical judgement.
Postoperative uncorrected visual acuity (logMAR)	1 month postoperatively	—
Subjective visual satisfaction	1 month postoperatively	National Eye Institute Visual Functioning Questionnaire 25 (VFQ-25). Graded on a scale from 1 to 5 with lower scores indicative of higher satisfaction.

Countries

United States

Contacts

CONTACTRenee Bondurant

Renee.Bondurant@eyespecialist.com727-450-4668

PRINCIPAL_INVESTIGATORNeel Desai, MD

The Eye Institute of West Florida

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 22, 2026