Mitochondrial Energy Metabolism in Burns

The Role of the Mitochondrian in the Metabolic Stress Response to Burn Trauma

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07643545

Acronym

Mito Burn

Enrollment

125

Registered

2026-06-11

Start date

2023-04-20

Completion date

2026-06-01

Last updated

2026-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burn Injury

Brief summary

The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study. During the study, we will collect the following information: * General background information such as date of birth, height, weight, and other basic information. * Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests. * Blood, urine, and tissue during surgeries you have during your stay.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

2 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Male or Female * Ages 2 years to 80 years * Requiring hospital admission for burn care * All races * All ethnicities

Exclusion criteria

* Age \< 2 years * Under 10 kg in body mass * Age \> 80 years * Active pregnancy * Unable to provide informed consent and no legal authorized representative present * Patient is considered moribund at the time of admission by the treating physician.

Design outcomes

Primary

Measure	Time frame	Description
Blood Bioenergetics	Through study completion, an average of 1 year	Peripheral Blood Mononuclear Cell (PBMC) respiration

Secondary

Measure	Time frame	Description
Blood metabolics signatures	Through study completion, an average of 1 year	Peripheral Blood Mononuclear Cell (PBMC) respiration

Countries

United States

Contacts

CONTACTCraig Porter, PhD

cporter@uams.edu5013643340

CONTACTLily Cheak, B.S.

lcheak@uams.edu5013643340

PRINCIPAL_INVESTIGATORCraig Porter, PhD

Arkansas Children's Research Institute

Outcome results