Muscle Oxygenation
Conditions
Keywords
muscle, magnetic resonance imaging, external pressure, muscle contraction
Brief summary
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
Detailed description
Participant will undergo a single MRI examination. Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a standard brace soft foam attached; blood pressure cuff will be partially inflated. Participant will also be asked to lift MRI compatible 10 lb. weight. Muscle oxygenation will be actively measured using MRI. No medications are being given, and no invasive devices are being used.
Interventions
PROCEDURECompression and Contraction
Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight.
Sponsors
Icahn School of Medicine at Mount Sinai
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Alert and oriented. * Able to lift 10lbs. and hold for 30 seconds * Not claustrophobic. * Intact sensation in right upper extremity.
Exclusion criteria
* Latex allergy or allergy to isopropyl alcohol. * Skin injury or decreased sensation on right upper extremity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle oxygen level | Day 1, during procedure | Using functional MRI to evaluate effect of muscle compression on muscle oxygen. Demonstrating statistically significant change in muscle oxygen in tissues with application of tissue compression and muscle contraction compared to the same, non-compressed tissues with only muscle contraction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Deep tissue oxygen level | Day 1, during procedure | Using functional MRI to evaluate the effect of muscle compression and contraction on deep tissue oxygen. Demonstrate statistically greater decreased tissue oxygenation in the deep soft tissues compared to the superficial tissues below the deforming element, during application of tissue compression, during muscle contraction as well during application of tissue compression and muscle contraction. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORYudell Edelstein, MD
Icahn School of Medicine at Mount Sinai
Outcome results
None listed