Induction, Letrozole, Misoprostol, Missed Abortion
Conditions
Brief summary
This study aimed to evaluate the effect of letrozole plus misoprostol to terminate non-viable pregnancies in first trimester compared with the use of misoprostol alone.
Detailed description
Inducing abortion by drugs is an alternative for surgery intervention, which has economic benefits with lower side effects and its rate of success is 60 to 95%. Letrozole is also one of aromatase inhibitors, which is used to stimulate ovulation in infertile women suffering ovulatory dysfunction. This drug is one of the main drugs for inhibiting aromatase, with a relatively short 45-hour half life, which is active orally and inhibits aromatase enzyme reversibly. Misoprostol is a relatively safe drug and of its side effects it is possible to mention to gestational effects, feeling of warmth, and shivering. Severe side effects of misoprostol consumption are severe bleeding and endometritis, with less than 1% prevalence based on studies.
Interventions
DRUGLetrozole + Misoprostol
Patients received 10 mg of Letrozole daily for three days, subsequently receiving 800 µg of Misoprostol every three hours via vaginal or sublingual routes.
DRUGMisoprostol
Patients received only 800 µg of Misoprostol.
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Age from 18 to 45 years. * Women with nonviable pregnancies undergoing 1st-trimester abortion.
Exclusion criteria
* Medical diseases like renal or liver disease. * Severe bleeding and shocked patients. * Inevitable abortion. * Hypersensitivity to any of the drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of bleeding | 7 days following the Misoprostol dose | Incidence of bleeding was recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of dosages of prostaglandins | 7 days following the Misoprostol dose | Number of dosages of prostaglandins was recorded. |
| Duration required for abortion | 7 days following the Misoprostol dose | Duration required for abortion was recorded. |
| Incidence of adverse effects | 7 days following the Misoprostol dose | Incidence of adverse effects such as nausea, vomiting, gastric distress, headache, fever, and shivers were recorded. |
Countries
Egypt
Outcome results
None listed