Comparison of Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer

Comparison of Gastroesophageal Reflux and Quality of Life Between Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer Patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07635836

Enrollment

Registered

2026-06-09

Start date

2026-05-01

Completion date

2027-10-01

Last updated

2026-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Double-tract Reconstruction, Gastric Cancer (GC), Tubular Gastric Anastomosis

Brief summary

This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA). Participants were divided into two groups based on the surgical procedure. We conducted a comparative analysis of postoperative outcomes by evaluating electronic medical records, postoperative gastroscopy, 24-hour esophageal pH monitoring, and relevant rating scales.

Interventions

PROCEDUREDouble-tract reconstruction

Patients underwent double-tract reconstruction after radical proximal gastrectomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Pathologically confirmed gastric adenocarcinoma by biopsy * Carcinoma of the upper gastric body or Siewert type II/III adenocarcinoma of the esophagogastric junction (AEG), with a clinical stage of cT1-3N0-1M0 * Age 18-75 years, with a performance status (PS) score of 0-2 * Candidates for planned surgical resection, eligible for either double-tract reconstruction or tubular gastric anastomosis based on preoperative assessment * No severe dysfunction of vital organs (liver, kidney, heart, lung, or brain), and no severe infection or uncontrolled chronic diseases

Exclusion criteria

* Presence of other malignant tumors or severe chronic diseases (e.g., severe diabetes mellitus, chronic kidney disease, decompensated cirrhosis, etc.) * Preoperative endoscopic diagnosis of Barrett's esophagus * Severe preoperative malnutrition (albumin \<30 g/L, prealbumin \<150 mg/L) * History of prior upper abdominal surgery, gastrointestinal malformation, or psychiatric disorders * Preoperative diagnosis of obstructive motor disorders of the cardia (including achalasia spectrum disorders) * Inability to cooperate with or complete the required postoperative examinations

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative reflux esophagitis	6 month after surgery	The diagnosis of reflux esophagitis was based on symptoms, endoscopic findings, and 24-hour esophageal pH monitoring.
Severity of reflux esophagitis	6 month after surgery	According to the diagnostic and grading criteria for reflux esophagitis, patients were classified into four categories: no reflux esophagitis, mild (LA-A/B), moderate (LA-C), and severe (LA-D).

Secondary

Measure	Time frame	Description
Postoperative nutritional recovery	1 year after surgery	The body weight change rate at different postoperative time points compared with preoperative levels, along with albumin, prealbumin, and hemoglobin levels, were comprehensively considered in the assessment of postoperative nutritional status.

Countries

China

Contacts

CONTACTHui Qu, Doctor of Medicine

doctorquhui@email.sdu.edu.cn+8618560085120

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 10, 2026