Brain Tumor, Cortical Blindness, Hemianopia Homonymous, Quadrantanopia, Stroke, Traumatic Brain Injury, Visual Field Defect, Visual Field Defect, Peripheral, Visual Field Loss
Conditions
Keywords
neuroplasticity, stroke, vision, TBI, brain tumor
Brief summary
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.
Interventions
BEHAVIORALHigh-level perceptual learning-based training
Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing
BEHAVIORALLow-level perceptual learning-based training
behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing
Sponsors
Georgetown University
American Heart Association
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Study Procedures Week 1: Pre-intervention visual assessment and functional magnetic resonance imaging (fMRI) scan (in-person study visit). Weeks 2-4: Participants complete at-home, online perceptual learning training using either low-level or high-level visual stimuli. End of Week 4: Online assessment to evaluate the spatial transfer of training effects. Weeks 5-6: Washout period to minimize potential carryover effects. Weeks 7-9: Participants complete the alternate at-home, online perceptual learning training condition (low-level or high-level visual stimuli). End of Week 9: Second online assessment to evaluate the spatial transfer of training effects. Week 10 (Final Visit): Post-intervention visual assessment and fMRI scan (in-person study visit). Approximately Week 24: Follow-up visual assessment and fMRI scan (in-person study visit). The timing of study visits and training sessions may be adjusted as needed to accommodate participants' health status or scheduling needs.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. 3. Unilateral or bilateral focal brain damage causing visual field loss. 4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year. 5. Eligible for MRI based on standard safety screening.
Exclusion criteria
1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation. 2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5. 3. Ocular disease or disorder.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in high-level perceptual discrimination performance | Week 2-4 or Week 7-9 of the study (depending on the order) | Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy. |
| Change in low-level perceptual discrimination performance | Week 2-4 or Week 7-9 of the study (depending on the order) | Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy. |
Countries
United States
Contacts
CONTACTTina Liu, PhD
Outcome results
None listed