Peritoneal Dialysis
Conditions
Keywords
Peritoneal Dialysis, exercise, Physical Performance, Muscle Strength, Body Composition
Brief summary
The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise. The main questions the study aimed to answer were: * Can regular exercise improve physical performance and muscle strength in people receiving peritoneal dialysis? * Can regular exercise improve body composition and blood markers related to muscle health? Before the exercise program, participants completed a one-month training period to learn the exercises and practice them safely. Participants in the exercise group: * Performed combined aerobic and resistance exercises for 8 weeks * Completed assessments before and after the exercise program Participants in the control group: * Continued their usual care * Completed assessments before and after the study period
Detailed description
People receiving peritoneal dialysis often experience reduced physical function, muscle weakness, and changes in body composition. This randomized controlled trial evaluated the effects of a combined aerobic and resistance exercise program in adults receiving peritoneal dialysis. Before the intervention, participants completed a one-month training and adaptation period to learn the exercises and ensure safe participation. Participants were then assigned to either an exercise group or a control group. The exercise group performed a structured combined aerobic and resistance exercise program for 8 weeks, while the control group continued usual care. Researchers evaluated physical performance, muscle strength, body composition, and blood markers related to muscle health before and after the intervention period. The study aimed to determine whether regular exercise could improve physical function and muscle health in people receiving peritoneal dialysis.
Interventions
BEHAVIORALCombined Aerobic and Resistance Exercise
Participants performed a structured combined aerobic and resistance exercise program for 8 weeks. Before the intervention period, participants completed a one-month training and adaptation phase to learn the exercises and ensure safe participation. The exercise program aimed to improve physical performance, muscle strength, and muscle health in people receiving peritoneal dialysis.
Sponsors
Dilek GİBYELİ GENEK
Muğla Sıtkı Koçman University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants were assigned to either an exercise group or a control group and followed in parallel throughout the study period
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged 18 years or older * Receiving peritoneal dialysis for at least 6 months * Ability to sit and stand independently
Exclusion criteria
* Myocardial infarction within the previous 6 months * History of cardiac surgery * Uncontrolled hypertension * Pericardial or pleural effusion * Aortic stenosis * Active lower extremity amputation, prosthesis, or fracture * History of osteoporotic fractures * Regular participation in sports or structured exercise * Advanced cognitive impairment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Physical Performance | Baseline and after 8 weeks of intervention | Changes in physical performance assessed using the 6-minute walk test after 8 weeks of combined aerobic and resistance exercise. |
| Changes in right handgrip strength | Baseline and after 8 weeks of intervention | Changes in right handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise. |
| Changes in left handgrip strength | Baseline and after 8 weeks of intervention | Changes in left handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise. |
| Changes in leg strength | Baseline and after 8 weeks of intervention | Changes in lower extremity muscle strength measured using a leg and back dynamometer after 8 weeks of combined aerobic and resistance exercise. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in flexibility | Baseline and after 8 weeks of intervention | Changes in flexibility assessed using the Modified Back-Saver Sit-and-Reach Test after 8 weeks of combined aerobic and resistance exercise. |
| Changes in Fat Tissue Index (FTI) | Baseline and after 8 weeks of intervention | Changes in Fat Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise. |
| Changes in Lean Tissue Index (LTI) | Baseline and after 8 weeks of intervention | Changes in Lean Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise. |
| Changes in serum IGF-1 levels | Baseline and after 8 weeks of intervention | Changes in serum insulin-like growth factor-1 (IGF-1) levels after 8 weeks of combined aerobic and resistance exercise. |
| Changes in serum ACTH levels | Baseline and after 8 weeks of intervention | Changes in serum adrenocorticotropic hormone (ACTH) levels after 8 weeks of combined aerobic and resistance exercise. |
| Changes in serum myostatin levels | Baseline and after 8 weeks of intervention | Changes in serum myostatin levels after 8 weeks of combined aerobic and resistance exercise. |
| Changes in serum irisin levels | Baseline and after 8 weeks of intervention | Changes in serum irisin levels after 8 weeks of combined aerobic and resistance exercise. |
Countries
Turkey (Türkiye)
Outcome results
None listed