Sedentary Behavior
Conditions
Keywords
Aerobic exercise, resistance training, sedentary women, exercise immunology
Brief summary
Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively. These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.
Detailed description
The effects of exercise on the immune system have been studied for many years. Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response. Regular exercise has been shown to increase individuals' physical fitness levels. Exercise is used in the prevention and treatment of various diseases. Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health. Regular exercise positively affects all systems of the organism, including the immune system. Changes in the immune system after acute and chronic exercise differ. The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals. While light to moderate exercise strengthens the immune system, intense exercise can suppress it. The effects of exercise on the immune system have been the subject of much research in recent years. However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood. Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system. In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response. This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation. Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels. The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.
Interventions
BEHAVIORALAerobic and resistance exercise
Because it was done on young girls who lead a sedentary lifestyle.
Sponsors
Inonu University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* University students aged 18-30 * Individuals who have engaged in recreational exercise at least two days a week for the past three months * Those with low or no smoking or alcohol consumption who volunteer to participate in the study.
Exclusion criteria
* Individuals who have had an infection or chronic illness in the last 6 months, * Those with a history of autoimmune disease, * Metabolic syndrome, or cardiovascular disease, * Those who have used antibiotics or anti-inflammatory drugs in the last 3 months, * Those who have suffered a serious injury during exercise or are unable to continue are not eligible.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in C-Reactive Protein (CRP) Levels | Baseline (Week 0) and Post-intervention (Week 6) | Serum C-reactive protein levels will be measured using an ELISA kit to evaluate systemic inflammation. (Unit of measurement: mg/L) |
| Change in Interleukin-6 (IL-6) Levels | Baseline (Week 0) and Post-intervention (Week 6) | Serum interleukin-6 levels will be analyzed to assess pro-inflammatory cytokine response. (Unit of measurement: pg/mL) |
| Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels | Baseline (Week 0) and Post-intervention (Week 6) | Serum tumor necrosis factor-alpha levels will be measured to evaluate pro-inflammatory cytokine activity. (Unit of measurement: pg/mL) |
| Change in Salivary Immunoglobulin A (IgA) Levels | Baseline (Week 0) and Post-intervention (Week 6) | Salivary Immunoglobulin A levels will be measured to evaluate mucosal immune response. (Unit of measurement: mg/dL) |
| Change in Immunoglobulin M (IgM) Levels | Baseline (Week 0) and Post-intervention (Week 6) | Serum Immunoglobulin M levels will be measured to assess acute infection and humoral immune response. (Unit of measurement: mg/dL) |
| Change in Immunoglobulin G (IgG) Levels | Baseline (Week 0) and Post-intervention (Week 6) | Serum Immunoglobulin G levels will be measured to assess long-term immune memory and humoral immune response. (Unit of measurement: mg/dL) |
| Change in Leukocyte (WBC) Count | Baseline (Week 0) and Post-intervention (Week 6) | Total leukocyte (White Blood Cell) count will be analyzed to assess general immune and inflammatory status. (Unit of measurement: cells/µL) |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORFahri Safa Çınarlı, Doç. Dr.
Inonu University
Outcome results
None listed