Alzheimer s Disease, Healhty
Conditions
Keywords
Alzheimer's disease, memory remediation, motor-enriched encoding, imagery, static imagery, dynamic imagery
Brief summary
In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050. With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs. Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions. Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory. For patients with motor impairments, motor imagery (MI) activates these networks without actual movement. Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images. This project aims to combine real action, MI, and dynamic visual supports to optimize memory. By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images. The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.
Detailed description
In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050. With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs. Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions. Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory. For patients with motor impairments, motor imagery (MI) activates these networks without actual movement. Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images. This project aims to combine real action, MI, and dynamic visual supports to optimize memory. By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images. The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.
Interventions
BEHAVIORALControl condition
Reading a sentence aloud and the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.
BEHAVIORALMotor mental imagery
Following the reading of each sentence, the participant is instructed to mentally simulate performing the action described in the sentence. And the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.
BEHAVIORALAction execution
After reading the sentence, the participant pantomimes the action described and The participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Intervention model description
A comparative repeated-measures crossover study in which each participant undergoes each experimental condition in succession.
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patient group: Diagnosis of Alzheimer's disease made by one of the consulting physicians-a neurologist and/or geriatrician (Dubois et al., 2014)-at the early stage, presenting with mild memory impairment of which the patient has been informed \- MMSE score of 21 or higher Control group: individuals without a diagnosis of Alzheimer's disease, but meeting the other criteria listed below * Enrollment in a social security program * Age 60 or older * French as a native language * Consent to participate
Exclusion criteria
* Uncorrected visual or hearing impairments * Language or motor impairments * Delirium or psychosis. * Medical treatment affecting vision, language, or motor skills (or participation in a study involving a drug or device that influences cognition). * Refusal to participate. * Inability to communicate * Persons deprived of liberty by a judicial or administrative decision and adults subject to a legal protection measure or unable to express their consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Free recall score | at 1 week | The free recall score corresponds to the number of sentences spontaneously retrieved by participants after learning, measuring free retrieval ability. |
Countries
France
Contacts
CONTACTCéline BORD, MD
CONTACTCéline LECLERCQ TRAUTVETTER, CDP
Outcome results
None listed