Alcohol Misuse, Critical Illness, Intensive Care (ICU)
Conditions
Keywords
Alcohol-Related Disorders, Critical Illness, Intensive Care Units
Brief summary
The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse outcomes in critically ill patients. The main question it aims to answer is: Do elevated CDT levels at ICU admission predict increased short-term mortality and adverse clinical outcomes in adult non-traumatic ICU patients? Participants admitted to the intensive care unit via the emergency department will have CDT levels measured as part of the study. Researchers will then collect and analyze clinical data, including mortality, duration of mechanical ventilation, delirium, ICU length of stay, renal replacement therapy, and ICU readmission rates, during hospitalization and follow-up.
Interventions
DIAGNOSTIC_TESTCarbohydrate-Deficient Transferrin (CDT) Measurement
Carbohydrate-deficient transferrin (CDT) measurement is performed at ICU admission as an objective biomarker of sustained hazardous alcohol consumption during the previous 1-3 weeks. CDT values are obtained from routinely collected blood samples in adult non-traumatic ICU patients admitted via the emergency department. The study is purely observational and does not involve administration of a therapeutic intervention or changes to standard clinical care. CDT levels are analyzed in relation to outcomes including 30-day mortality, ICU length of stay, mechanical ventilation, delirium, renal replacement therapy, and ICU readmission.
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all patients ≥ 18 admitted to the Department of Emergency Medicine and subsequently transferred to an in-house intensive care unit (ICU)
Exclusion criteria
* Patients transferred to other hospital departments prior to completion of intensive care * Patients admitted directly to the ICU without passing the ED * Patients admitted to intermediate care units * Patients with pre-existing or newly diagnosed hepatic cirrhosis * Patients with known or obvious pregnancy will be excluded. * Patients with no vascular access
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The primary outcome of the study is 30-day all-cause mortality in ICU patients. | From ICU admission to 30 days after ICU admission | 30-day all-cause mortality is defined as death from any cause occurring within 30 days after ICU admission. Mortality status will be assessed using patient medical records and, if unavailable, through the Austrian "Zentrales Personenstandsregister" (Central Civil Status Register), which documents registered deaths. Outcomes will be compared between patients with elevated and non-elevated carbohydrate-deficient transferrin (CDT) levels measured at ICU admission. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| In-hospital mortality | From hospital admission to hospital discharge evaluated 6 Months after study inclusion | Death from any cause occurring during the index hospital stay. |
| ICU length of stay | From ICU admission to ICU discharge evaluated 6 Months after study inclusion | Duration of stay in the intensive care unit, measured in days from ICU admission to ICU discharge. |
| Duration of mechanical ventilation | From initiation of mechanical ventilation to successful discontinuation during ICU stay evaluated 6 Months after study inclusion | Total duration of mechanical ventilation during the ICU stay, measured in hours or days. |
| Illness severity score | Evaluated from the documentation 6 Months after study inclusion | Severity of illness assessed using TISS(-A), with a higher score signaling higher severity |
Countries
Austria
Contacts
CONTACTJuergen Grafeneder, MD, PhD MSc
Outcome results
None listed