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End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07632430
Enrollment
3500
Registered
2026-06-08
Start date
2024-01-01
Completion date
2026-09-30
Last updated
2026-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest, Out-Of-Hospital, End-Tidal Carbon Dioxide, Prehospital Emergency Medical Services, Prehospital Resuscitation

Brief summary

The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2 (positive/negative) is a better predictor of patient survival to discharge. The secondary aim of this project is to identify significant predictors of neurologically intact patient survival as indicated by a cerebral performance category (CPC) score of 1-2.

Interventions

None listed

Sponsors

Office of the Medical Director for EMS in Oklahoma City and Tulsa
Lead SponsorOTHER
Medtronic
CollaboratorINDUSTRY

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* EHR's resulting from 9-1-1 response * Adult patients (aged 18+ at time of cardiac event) * experiencing out-of-hospital cardiac arrest (OHCA) * transported by an agency under OMD oversight * must have at least 2 EtCO2 values captured during care

Exclusion criteria

* EHR's resulting from inter-facility scheduled or unscheduled medical transfers * pediatric patients (those aged \<18 at time of incident) or unknown age * ROSC obtained prior to arrival of EMS * insufficient vital sign data

Design outcomes

Primary

MeasureTime frameDescription
Survival to Hospital Discharge90 dayslack of terminiation of CPR during prehospital or in hospital care

Secondary

MeasureTime frameDescription
Neurologically Intact Patient Survival90 daysBased on Gasgow-Pittsburgh Cerebral Performance Category (CPC) score which ranges from 1 (best) to 5 (worst). Neurologically intact is defined as a score of 1-2 among survivors

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 10, 2026