Skip to content

Will a Hands on Technique Applied to the Face Increase the Tear Production in Participants

Osteopathic Manipulative Treatment of the Sphenopalatine Ganglion for Induction of Lacrimation: A Pilot Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07632183
Enrollment
30
Registered
2026-06-08
Start date
2024-10-08
Completion date
2027-06-01
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Increased Production of Tears

Keywords

Osteopathic Manipulative Medicine, Osteopathic Manipulative Technique, tear production, sphenopalatine ganglion, sphenopalatine ganglion release

Brief summary

The goal of this interventional study is to learn if a hands on technique will increase tear production in patients aged 45 and younger, without a history of eye issues. The main question it aims to answer is: Will there be an increase in tear production using a specific hand on technique applied inside the mouth? Participants will have a small, sterile, piece of paper that will be placed briefly in their eye. This is done to take measurements of tear production. A doctor will then perform a hands on technique in which a gloved finger is placed in the participants' mouth to release the tension that is found. After the technique is completed, the participants' eye will be retested with the tear strip. The tear test strip will be applied twice more on the following visits at 2 days after the first session and one week after the first session

Detailed description

This study is designed as an experimental pilot study for proof of concept with pre- and post- test measurements taken on the same individual. We will be measuring at time points 0 (baseline), immediately after treatment (within 5 minutes), 2 day, and 1 week each with a standardized Schirmer's Test for tear production. This study is intended to gather data on around 30 individuals within the set inclusion/exclusion criteria. The proposed mechanism is that stimulation of the parasympathetic nervous system via the sphenopalatine ganglion may induce increased lacrimation and provide relief (of yet unknown duration or efficacy) for patients who report sensations of dry eye

Interventions

PROCEDUREsphenopalatine ganglion release

Employs the technique of sphenopalatine ganglion release through use of manual manipulation with a gloved finger intraorally

Sponsors

Edward Via Virginia College of Osteopathic Medicine
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* age 18-45 * 1st- 4th year medical students, faculty and staff volunteers at specific College of Osteopathic medicine campus

Exclusion criteria

* volunteers who have had ophthalmologic surgery * diagnosis of dry eye syndrome * diagnosis of temporomandibular joint disease * individuals who are greater than 45 years of age.

Design outcomes

Primary

MeasureTime frameDescription
Schirmer measurements on ParticipantsFrom enrollment to the end of treatment at 1 weekWill measure tear production via the Schirmer test strips and will compare pre and post intervention

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 9, 2026