Post-op Prednisone and Glucose Monitoring in TKA

Postoperative Prednisone Regimen in TKA and Its Effect on Continuous Glucose Levels

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07630896

Enrollment

104

Registered

2026-06-05

Start date

2026-07-01

Completion date

2028-03-01

Last updated

2026-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, Total Hip Arthroplasty (THA), Unicompartmental Knee Arthroplasty

Keywords

Post-operative pain, Prednisone, Continuous Glucose Monitoring

Brief summary

This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels monitored continuously.

Interventions

DRUGPrednisone

40 mg daily for 5 days

DEVICEContinuous Glucose Monitor

Provides real-time glucose readings for up to 14 days

OTHERInkWell Health Tattoos

Temporary medical-grade tattoos that provide real-time monitoring of knee swelling and range of motion

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Undergoing Primary Unicompartmental Knee Arthroplasty or Total Hip Arthroplasty * Age 18 and above

Exclusion criteria

* Steroid therapy * Narcotic use within past 3 months * History of corticosteroid intolerance * Pregnancy * Uncontrolled diabetes * Doesn't own smart phone Drop Criteria: \- 2nd dose of IV dexamethasone

Design outcomes

Primary

Measure	Time frame	Description
Pain at Rest	2 weeks	Pain intensity at rest will be measured using the 11-point Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain). The NRS is a validated and standardized tool for assessing patient-reported pain.
Pain with Ambulation	2 weeks	Pain intensity with ambulation will be measured using the 11-point Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain). The NRS is a validated and standardized tool for assessing patient-reported pain.

Secondary

Measure	Time frame	Description
Swelling	2 weeks	Knee joint circumference will be measured in centimeters at the joint line.
Range of Motion	2 weeks	—
Opioid Consumption	2 weeks	—
Continuous Glucose Levels	2 weeks	—
Adverse Outcomes	2 weeks	Total number of adverse events related to steroid treatment will be recorded.

Countries

United States

Contacts

CONTACTJacqueline Lenahan

jl5092@cumc.columbia.edu(212) 305-8193

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 6, 2026