Cardiovascular (CV) Risk
Conditions
Keywords
air pollution, air purifiers, HEPA filtration, cardiovascular risk, biomarkers
Brief summary
The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.
Detailed description
Conduct a randomized crossover pilot trial with 66 participants to calculate preliminary effect size estimates to inform a larger crossover efficacy trial: We will: 1) enroll 66 individuals living in low and high traffic areas in Hartford (N=44) and a highly polluted urban areas in Boston Chinatown (N=22); and 2) install full filtration DIYAPs and sham DIYAPs for 30 days each in a randomized crossover trial design with a 14-day wash-out in between; and 3) measure seated and ambulatory BP, administer the SF-12v2, the Trail Making Test Part B, collect blood, and measure both indoor and outdoor PM (in size bins).
Interventions
OTHERPortable air purifiers with HEPA filtration
Portable air purifiers filter air and reduce exposure to air pollutants, in this case, airborne particulate matter
OTHERPortable air purifiers without filtration (sham)
Air purifiers with filters removed (sham)
Sponsors
Douglas Brugge
National Heart, Lung, and Blood Institute (NHLBI)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Double blind, randomized crossover
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Age 40 years or older Speaks English, Vietnamese, and/or Chinese Cognitive capacity to respond to questionnaires Lives fulltime at the current address, adjacent (\< 200 meters) to roadways with large traffic volumes Must have one or more risk factors (hypertension or elevated blood pressure, pre-diabetes or diabetes or elevated blood sugar levels, elevated cholesterol levels, body mass index 25 or greater)
Exclusion criteria
Pregnant Works between the hours of 10 PM and 6 AM Sources of smoke in the living space (such as candles, incense, marijuana, wood stove, fireplace) almost every day/every day. Every day exposure to motor vehicle exhaust (from cars, trucks, buses, trains), including heavy street or highway traffic. Currently smoking or vaping Others smoking or vaping indoors, in the living space. Within the past 5 years, a diagnosis of heart attack, heart disease, stroke, blood clots or pulmonary embolism, cancer requiring surgery and/or chemo/radiation therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | Day 0, 30, 45, and 75 | Periferal blood pressure, seated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IL-1beta | Day 0, 30, 45, and 75 | Blood inflammatory biomarker |
Contacts
CONTACTDoug Brugge, PhD
PRINCIPAL_INVESTIGATORDoug M Brugge
UConn Health
Outcome results
None listed