Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up

Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of Diffusion Tensor Imaging (DTI) and Resting State Functional MRI (Rs-fMRI) to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07628257

Acronym

GlioConnect

Enrollment

Registered

2026-06-04

Start date

2026-09-15

Completion date

2030-09-15

Last updated

2026-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioblastoma

Brief summary

The aim of this study is to determine whether the diffuse cerebral metabolic disturbances observed in glioblastoma are exclusively linked to the direct and indirect effects of tumor infiltration (particularly structural disconnection), or whether they also reflect a more global alteration of neurometabolic and neurovascular coupling mechanisms. This approach thus aims to better understand the pathophysiological basis of cognitive impairment in glioblastoma and to characterize the impact of the disease at the level of brain networks.

Interventions

OTHER18F-FDG PET/MRI with additional DTI and rs-fMRI sequences

fluorodeoxyglucose (Fluor18) (18F-FDG) PET/MRI with additional DTI and rs-fMRI sequences correlation with neuropsychological tests

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients * Patients with glioblastoma * Patients treated in the Nuclear Medicine \& Molecular Imaging Department of the Strauss Institute for PET/MRI scans for: * Preoperative metabolic evaluation of a brain-expanding lesion

Exclusion criteria

* Contraindications to MRI * Minor or incapacitated adult * Patient deprived of liberty * Patient under legal guardianship * Patient unable to consent * Pregnant or breastfeeding woman

Design outcomes

Primary

Measure	Time frame
Correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance before surgery	Before surgery

Secondary

Measure	Time frame
correlation between cortical energy activity (FDG PET), axonal morphological connectivity (DTI - MRI), synchronous neuronal activity (rs-fMRI), and preoperative neuropsychological performance after surgery	After surgery, through the study, i.e. for a maximum of 2 years

Countries

France

Contacts

CONTACTClaire VIT

promotion-rc@institut-strauss.fr(0)388258529

CONTACTManon VOEGELIN

promotion-rc@institut-strauss.fr(0)368339523

PRINCIPAL_INVESTIGATORIzzie-Jacques NAMER, MD, PhD

Institut Public De Cancerologie Strauss Europe

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 5, 2026