Laryngeal Lesions, Systemic Inflammatory Process
Conditions
Keywords
Laryngeal lesions, systemic inflammatory process, panimmun inflamation
Brief summary
The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.
Detailed description
Benign laryngeal lesions are generally nodules, polyps, or cysts that form due to overuse of the voice or vocal cord trauma. Reinke's edema, also within this group, is a benign laryngeal condition characterized by the accumulation of gelatinous fluid in the superficial lamina propria of the vocal cords. It is usually associated with chronic irritation, particularly smoking, and is frequently seen in middle-aged individuals with a long history of tobacco use. Previous experimental studies have shown that cigarette smoke triggers inflammatory responses in vocal cord fibroblasts and increases the production of inflammatory mediators. The cellular and systemic inflammatory processes triggered by irritation due to chronic smoking are still not fully understood. In recent years, systemic inflammation markers derived from routine hemogram parameters have attracted attention as low-cost and reliable potential biomarkers in various inflammatory and neoplastic diseases. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), hemoglobin-eosinophil ratio (HEO), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV), as well as more comprehensive indices reflecting both inflammatory and nutritional status such as Neutrophil-Albumin Ratio (NPAR) and HALP (Hemoglobin, Albumin, Platelet Ratio), are inexpensive and readily available indicators of systemic inflammation. However, a review of the literature reveals a lack of studies examining the relationship between benign and malignant laryngeal lesions and systemic inflammation through these comprehensive indices (PIV and NPAR). The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.
Interventions
OTHERLaryngeal polyps
Bening laryngeal lesions
OTHERLaryngeal nodules
Bening laryngeal lesions
OTHERLaryngeal cysts
Bening laryngeal lesions
OTHERReinke's edema
Bening laryngeal lesions
OTHERPapillomas
Premalign laryngeal lesions
OTHERDysplasia
Premalign laryngeal lesions
OTHERHigh-risk premalignant lesions
Premalign laryngeal lesions
OTHERMalignant vocal cord lesions
Malign laryngeal lesions
OTHERAsymptomatic smokers without vocal cord lesions
None laryngeal lesions
Sponsors
Antalya Health Sciences University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 years and older * Patients with a diagnosis of vocal cord lesion via endoscopic or surgical means * Patients with complete blood count and albumin data in their hospital records
Exclusion criteria
* Acute infection * Autoimmune disease * Other malignancy * Steroid use * Hematological disease * Systemic inflammatory disease * Missing laboratory data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determining the diagnostic accuracy of PIV | Postoperative 1 month | PIV (pan-immune-inflammation value) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Determining the diagnostic accuracy of NLR | Postoperative 1 month | NLR (neutrophil-lymphocyte ratio) |
| Determining the diagnostic accuracy of PLR | Postoperative 1 month | PLR (platelet-lymphocyte ratio) |
| Determining the diagnostic accuracy of HEO | Postoperative 1 month | HEO (hemoglobin-eosinophil ratio) |
| Determining the diagnostic accuracy of SII | Postoperative 1 month | SII (systemic immune-inflammation index) |
| Determining the diagnostic accuracy of NPAR | Postoperative 1 month | NPAR (neutrophil-albumin ratio) |
| Determining the diagnostic accuracy of HALP | Postoperative 1 month | HALP (hemoglobin, albumin, platelet ratio) |
Countries
Turkey (Türkiye)
Contacts
CONTACTNuray Ensari
PRINCIPAL_INVESTIGATORNuray Ensari
University of Health Sciences, Antalya Training and Research Hospital
Outcome results
None listed