Acute Ischemic Stroke
Conditions
Brief summary
Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed to thrombosis, increases the risk of thrombus formation. Once dislodged from the atrial cavity and traveling to the cerebral arteries, these thrombi can cause a cardioembolic stroke. The main risk factors for atrial cardiomyopathy (ACM) and AF are metabolic syndrome and aging. ACM is a condition that is difficult to diagnose because it is not clearly defined, except through histological analysis. Guided by the results of our experimental approaches, the investigators aim to address this challenge by examining ACM through the lens of one of its complications: cardioembolic stroke. BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophic factor involved in inflammatory and metabolic processes that may play a key role in the development of these complications. This study explores the association between circulating levels of BDNF and the morphological and metabolic characteristics of ACM, as assessed by cardiac and brain imaging studies
Interventions
BIOLOGICALCirculating BDNF levels measured via blood sample
Diagnosis of cardioembolic stroke according to the TOAST13 classification, adjudicated with a blinded review of biomarker data by the treating of a neurologist upon the patient' s hospital discharge
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Individuals who provided informed consent * Diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI) * Patient admitted to the USINV of the Department of General, Vascular, and Degenerative Neurology at the Dijon Bourgogne University Hospital during the inclusion period * Underwent a combined cardiac and brain CT scan within 24 hours of admission for stroke
Exclusion criteria
* A person subject to a legal protective measure (guardianship, conservatorship) * A person subject to a judicial safeguard measure * A pregnant woman, a woman who has recently given birth, or a breastfeeding woman * An adult who is legally incapacitated or unable to give consent, * A minor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of cardioembolic stroke according to the TOAST classification, adjudicated with a blinded review of biomarker data by the treating of a neurologist upon the patient' s hospital discharge. | At hospital discharge (approximately 5 to 10 day after admission) |
Countries
France
Contacts
CONTACTCharles GUENANCIA, Pr
Outcome results
None listed