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Neural Mechanisms of Emotion-behaviour Interactions

Neural and Cognitive Mechanism of Adaptive and Maladaptive Interplay Between Emotions in Behaviour in Naturalistic Tasks

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07623746
Acronym
EMOBB
Enrollment
120
Registered
2026-06-03
Start date
2026-10-01
Completion date
2030-10-10
Last updated
2026-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteer

Keywords

FMRI, Emotions, Cognition

Brief summary

Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions. Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera. The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.

Interventions

OTHERFunctional Magnetic Resonance Imaging (fMRI)

Participants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.

Sponsors

Hospices Civils de Lyon
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* 18-45 years old, * fluent French speakers, * healthy, * without a beard at the time of testing, * right-handed, * being able to use both hands * BMI between 18.5 and 30 * give written informed consen * for women: contraception;

Exclusion criteria

* neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders) * pregnancy or breast-feeding * under guardianship, currently admitted to a psychiatric hospital other than for research purposes) * not wanting to be informed of abnormalities detected during MRI scan, * taking part in other studies with exclusion periods, * MRI

Design outcomes

Primary

MeasureTime frameDescription
Brain activity in regions of interestDay 0Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).

Secondary

MeasureTime frameDescription
Brain activity during task 1 (Self-organization under threat)Day 0Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Brain activity during task 2 (Self-organization and learning)Day 0Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Brain activity during task 3 (Self-organization and social context)Day 0Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).

Countries

France

Contacts

CONTACTJacqueline SCHOLL, PhD
jacqueline.scholl@inserm.fr+ 33
PRINCIPAL_INVESTIGATORJacqueline SCHOLL, PhD

Institut National de la Santé Et de la Recherche Médicale, France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 4, 2026