Frailty, Frailty/Sarcopenia
Conditions
Keywords
geriatric rehabilitation, elderly, frailty, Complex geriatric assessment, Cardiopulmonary exercise testing
Brief summary
All participants underwent comprehensive geriatric assessment (CGA) and cardiopulmonary exercise testing (CPET). A personalized management program was developed for each patient, including recommendations on physical exercise, nutrition, correction of geriatric syndromes, optimization of somatic status, and medication therapy adjustment. The program was delivered in a hospital setting over 3-5 days, with recommendations provided for continuation at the outpatient stage for 6 months. Upon completion of the 6-month program, CGA and CPET were repeated to evaluate the effectiveness of the programs.
Detailed description
All participants underwent comprehensive geriatric assessment (CGA) and cardiopulmonary exercise testing (CPET). After this the participants will undergo geriatric rehabilitation programs. The participation duration will not exceed 6.5 months including the screening period. The study comprises three periods: * screening (1-14 days) * a treatment course of 3-5 days * a follow-up period of 6 months On screening visit Study procedures will include * Informed consent signing * The Comprehensive Geriatric Assessment (CGA) * Cardiopulmonary exersize test (CPET) * The recommendations on a program of geriatric rehabilitation based on CGA and CPET The inpatient phase will last 3-5 days and will include: * Implementation of the comprehensive personalized management program * Issuance of recommendations for continuing the program at the outpatient stage Patients will be randomized into active follow-up and passive follow-up groups based on the number of scheduled telephone contacts using a specially designed structured questionnaire. Active follow-up group: short version of the telephone contact every 1 month during the first three months, with the full version at 3 months. Passive follow-up group: full version of the telephone contact at 3 months. The total duration of the outpatient follow-up phase will be 6 months. Final visit will be performed at the end of rehabilitation program. It will include: * The CGA and CPET * The evaluation of the results of 6 months geriatric rehabilitation program * The recommendations on a long-term geriatric rehabilitation
Interventions
OTHERGeriatric rehabilitation program based on CGA and CPET
Geriatric rehabilitation program based on CGA and CPET will be performed under physicians' tight control over 3-5 days, followed by outpatient continuation for 6 months. After 6 months, CGA and CPET will be repeated to evaluate program effectiveness.
Sponsors
Pirogov Russian National Research Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
his is a prospective, non-randomized, parallel-group study. Participants are assigned to one of three final groups (Robust, Prefrailty, Frailty) based on a sequential algorithm using the questionnaire "Vozrast ne pomekha" (0-7 points) and the Short Physical Performance Battery (SPPB; 0-12 points): Step 1 - Questionnaire "Vozrast ne pomekha" score: \< 3 points → further stratified by SPPB: SPPB 10-12 → Robust SPPB 8-9 → Prefrailty SPPB ≤7 → Frailty 3-4 points → further stratified by SPPB: SPPB ≥8 → Prefrailty SPPB ≤7 → Frailty ≥ 5 points → Frailty (regardless of SPPB score)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. Men and women aged 60 and older who wanted to participate in the study and signed a consent form.
Exclusion criteria
1. Presence of acute diseases or exacerbation of chronic diseases within 2 weeks prior to study inclusion. 2. Presence of active malignant oncological diseases. 3. Presence of severe cognitive impairment (dementia) and sensory deficits that may affect the ability to perform or evaluate study procedures. 4. Presence of anemia (hemoglobin level \<110 g/L). 5. Presence of musculoskeletal disorders or peripheral artery disease that may affect mobility and the ability to undergo study procedures. 6. Presence of one or more contraindications to exercise testing. 7. Any other condition that, in the investigator's opinion, may preclude the patient's participation in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| functional status dynamics | 6 months | Instrumental and Basic Activity Daily Life scale score |
| Change in aerobic exercise capacity | 6 months | eak oxygen uptake (VO₂ peak) measured during cardiopulmonary exercise testing (CPET) |
Countries
Russia
Contacts
PRINCIPAL_INVESTIGATOROlga N Tkacheva, Dr.
Pirogov Russian National Research Medical University, the Russian Research and Clinical Center for Gerontology
Outcome results
None listed