Sleep Disturbance, Visual Health
Conditions
Keywords
Gac fruit oil, Momordica cochinchinensis, Sleep quality, Visual health, Depressive symptoms
Brief summary
This study evaluated the effects of gac fruit oil supplementation on visual health, sleep quality, depressive symptoms, cognitive function, and brain imaging parameters in adults with sleep disturbance. Participants aged 40 to 65 years were recruited and received gac fruit oil capsules for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day. Assessments were performed before and after the intervention, including macular pigment measurement, ocular surface disease evaluation, tear film analysis, contrast sensitivity testing, accommodative microfluctuation analysis, optical coherence tomography, the Pittsburgh Sleep Quality Index, a depression scale, the Mini-Mental State Examination, and brain magnetic resonance imaging. The study aimed to explore whether 30 days of gac fruit oil supplementation was associated with changes in visual function, sleep quality, mood-related measures, cognitive function, and brain imaging findings.
Interventions
DIETARY_SUPPLEMENTGac Fruit Oil Capsules
Participants took gac fruit oil capsules orally for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day, for a total of four capsules per day.
Sponsors
Yuanpei University of Medical Technology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
All participants received the same intervention: gac fruit oil capsules for 30 days. Outcomes were assessed before and after the intervention.
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 40 to 65 years. * Participants with sleep disturbance. * Participants who were willing to participate in the study and provide written informed consent.
Exclusion criteria
* History of ocular surgery. * Cataract. * Glaucoma. * Current supplementation intended to increase macular pigment level. * Pregnancy. * Severe illness. * Use of medications that may affect or stimulate sleep. * Use of medications that promote sleep. * Unable to undergo magnetic resonance imaging, including but not limited to individuals with a pacemaker, artificial heart valve, metal aneurysm clip, metallic tracheostomy tube, possible metallic fragments in the orbit, cochlear implant, implanted electrodes, neurostimulator, implanted drug infusion device, hemostatic clips, vascular stents, claustrophobia, previous brain surgery, or history of traumatic brain injury with implanted metal materials. * Participants who experienced discomfort during the study or wished to withdraw could discontinue participation at any time without providing a reason.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Sleep Quality | Baseline and 30 days | Sleep quality was assessed using the Pittsburgh Sleep Quality Index before and after 30 days of gac fruit oil supplementation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Depressive Symptoms | Baseline and 30 days | Depressive symptoms were assessed using a depression scale before and after 30 days of gac fruit oil supplementation. |
| Change in Macular Pigment Level | Baseline and 30 days | Macular pigment level was assessed using a macular pigment screener before and after 30 days of gac fruit oil supplementation. |
| Change in Ocular Surface Disease Symptoms | Baseline and 30 days | Ocular surface disease symptoms were assessed using the Ocular Surface Disease Index before and after 30 days of gac fruit oil supplementation. |
| Change in Tear Film Parameters | Baseline and 30 days | Tear film parameters were assessed using a non-contact ocular surface analyzer before and after 30 days of gac fruit oil supplementation. |
| Change in Contrast Sensitivity | Baseline and 30 days | Contrast sensitivity was assessed using the CVS-1000 contrast sensitivity test before and after 30 days of gac fruit oil supplementation. |
| Change in Accommodative Microfluctuation | Baseline and 30 days | Accommodative microfluctuation was assessed using an accommodative microfluctuation analyzer before and after 30 days of gac fruit oil supplementation. |
| Change in Retinal Structure | Baseline and 30 days | Retinal structure was assessed using optical coherence tomography before and after 30 days of gac fruit oil supplementation. |
| Change in Cognitive Function | Baseline and 30 days | Cognitive function was assessed using the Mini-Mental State Examination before and after 30 days of gac fruit oil supplementation. |
| Change in Brain Magnetic Resonance Imaging Parameters | Baseline and 30 days | Brain magnetic resonance imaging parameters were assessed before and after 30 days of gac fruit oil supplementation. |
Countries
Taiwan
Contacts
PRINCIPAL_INVESTIGATORChao-Kai Chang
Yuanpei University of Medical Technology
Outcome results
None listed