The Implementation of Genetic Risk for Colorectal Cancer Screening

Prospective Trial for the Implementation of Genetic Risk for Colorectal Cancer Screening

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07621757

Acronym

PRO-GENE-COLON

Enrollment

100

Registered

2026-06-02

Start date

2026-06-01

Completion date

2027-05-31

Last updated

2026-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Adenoma, Colorectal Cancer, Colorectal Polyp

Brief summary

The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies? 2. How do colonoscopy outcomes compare between genetic risk groups?

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

\- Due for initial screening colonoscopy per current guidelines

Exclusion criteria

* Prior colonoscopy * Prior personal history of colorectal cancer or inflammatory bowel disease * Medical contraindications to colonoscopy/sedation

Design outcomes

Primary

Measure	Time frame
Number of scheduled colonoscopies in each genetic risk group	One year following enrollment

Secondary

Measure	Time frame
Number of polyps and/or adenomas found through colonoscopy in each genetic risk group	One year following enrollment

Countries

United States

Outcome results