Frailty and Severity as Determinants of Hospital Cost in the ICU

Frailty and Severity as Determinants of Hospital Cost in the Intensive Care Unit: A Retrospective Cohort Study With Partial Economic Evaluation.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07621276

Acronym

FRESH-ICU

Enrollment

142

Registered

2026-06-02

Start date

2024-01-01

Completion date

2025-06-01

Last updated

2026-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness, Frailty, Hospital Costs

Keywords

Intensive Care Unit, SAPS 3, mFI-11, Resource Allocation, Critical

Brief summary

This study evaluated the association between baseline frailty (mFI-11) and acute illness severity (SAPS 3) with real hospital costs in adult patients admitted to the Intensive Care Unit (ICU). The objective was to determine if frailty and severity are independent predictors of resource consumption.

Detailed description

A retrospective cohort study was conducted at Hospital H+ Querétaro involving 142 adult patients admitted to the ICU between January 2024 and May 2025. Baseline frailty was calculated using the 11-item Modified Frailty Index (mFI-11), and acute severity was assessed with the SAPS 3 score. Total hospital costs were obtained from institutional financial records. Multivariate models were used to adjust for comorbidities (Charlson Index) and other clinical variables to identify independent determinants of hospital expenditure.

Interventions

OTHERTotal Real Hospital Cost.

The total monetary expenditure (expressed in Mexican Pesos) generated during the hospital stay, as recorded in the institutional financial database.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 18 years or older. * Admission to the ICU between January 1, 2024, and May 31, 2025. * Complete medical records allowing for the calculation of mFI-11, SAPS 3, and Charlson Index. * Availability of institutional records regarding actual hospital costs.

Exclusion criteria

* Incomplete records for primary exposure or outcome variables. * Patients transferred from other institutions without sufficient baseline data. * Severe inconsistencies in cost records. * Subsequent readmissions where costs cannot be independently attributed to the index episode.

Design outcomes

Primary

Measure	Time frame	Description
Total Real Hospital Cost	From ICU admission to hospital discharge (approximately 17 months of data collection period).	The total monetary expenditure (in local currency) recorded in the institutional administrative database for the hospital episode, from admission to discharge or death.

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 18, 2026