Obesity
Conditions
Keywords
: circuit training, vascular function, cardiometabolic, physical fitness, obesity
Brief summary
Obesity is associated with impaired vascular function, metabolic dysfunction, and reduced physical fitness, which increase cardiovascular disease risk. This randomized controlled trial aims to investigate the effects of a 12-week home-based circuit training program using light-to-moderate resistance on vascular health, body composition, metabolic function, resting metabolic rate, substrate oxidation, physical activity, and physical fitness in adults with obesity. Participants will be randomly assigned to either a home-based circuit training group or a control group maintaining usual daily activities. The findings may support the use of home-based exercise as a practical and time-efficient strategy for obesity management and cardiovascular risk reduction.
Detailed description
Obesity is a major public health concern associated with endothelial dysfunction, arterial stiffness, metabolic impairment, and reduced physical fitness. Although exercise training is recommended for obesity management, adherence to supervised exercise programs may be limited by time constraints and accessibility. Home-based circuit training may provide a feasible alternative that combines aerobic and resistance exercise within a time-efficient format. This randomized controlled trial investigates the effects of a 12-week home-based circuit training intervention on vascular function, body composition, metabolic function, resting metabolic rate, substrate oxidation, physical activity, and physical fitness in adults with obesity. Participants with obesity (BMI ≥ 27.5 kg/m²) will be randomly assigned to either a circuit training group or a control group. The intervention group will perform home-based circuit training using light-to-moderate resistance three times weekly for 12 weeks, while the control group will maintain usual activities. Primary vascular outcomes include flow-mediated dilation, carotid intima-media thickness, brachial-ankle pulse wave velocity, and post-occlusive reactive hyperemia. Secondary outcomes include body composition, fasting plasma glucose, resting metabolic rate, substrate oxidation, physical activity, muscular strength, flexibility, and cardiorespiratory fitness. The study aims to determine whether home-based circuit training can improve vascular and metabolic health and serve as a practical strategy for reducing cardiovascular risk in adults with obesity.
Interventions
BEHAVIORALHome-Based Circuit Training
Participants will perform a 12-week home-based circuit training program three times per week. Each session includes warm-up, circuit-based exercises targeting major muscle groups, and cool-down activities. The intervention is designed to improve vascular and metabolic health in adults with obesity. The training program consisted of two phases: phase 1 (weeks 1-6) and phase 2 (weeks 7-12). During phase 1, participants performed resistance exercises at an intensity of 65-70% of one-repetition maximum (1RM). Each exercise consisted of 12 repetitions, with a 1-minute rest between exercises. The lifting tempo was maintained at 2:2 (concentric: eccentric). Participants completed 8 exercises per circuit for a total of 3 circuits, with a 2-minute rest between circuits. During phase 2, the intensity was increased to 70-75% of 1RM, while maintaining 12 repetitions per exercise. The rest interval between exercises was reduced to 30 seconds, with the same lifting tempo (2:2). Participants complete
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants will be randomly assigned to either a home-based circuit training group or a control group in a parallel-group design.
Eligibility
Sex/Gender
ALL
Age
19 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Adults with obesity according to the Asia-Pacific criteria (body mass index \[BMI\] ≥ 27.5 kg/m²). * Able to participate in a home-based exercise program. * Willing to provide written informed consent.
Exclusion criteria
* History of uncontrolled diabetes (HbA1c ≥ 10% or blood glucose ≥ 200 mg/dL). * Uncontrolled hypertension (≥ 140/90 mmHg). * Cardiovascular disease. * Chronic obstructive pulmonary disease. * Orthopedic conditions limiting exercise participation. * Participation in regular exercise programs or sports activities within the previous 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular Function | Baseline and 12 weeks | Change in flow-mediated dilation from baseline to 12 weeks. |
Countries
Thailand
Contacts
STUDY_DIRECTORDaroonwan Suksom, PhD
Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand
PRINCIPAL_INVESTIGATORTunyakarn Worasettawat, PhD
Faculty of Sports Science, Chulalongkorn University, Bangkok, Thailand
STUDY_CHAIRHirofumi Tanaka, PhD
Department of Kinesiology and Health Education, The University of Texas at Austin, USA
Outcome results
None listed