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Ultrasound-Guided Transversalis Fascia Plane Block Versus Quadratus Lumborum Plane Block for Analgesia After Appendectomy in Pediatrics

Ultrasound-Guided Transversalis Fascia Plane Block Versus Quadratus Lumborum Plane Block for Analgesia After Appendectomy in Pediatrics: A Prospective Randomized Study

Status
Enrolling by invitation
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07618650
Enrollment
70
Registered
2026-06-01
Start date
2025-06-30
Completion date
2026-05-20
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendectomy, Quadratus Lumborum Block, Transversalis Fascia Plane Block

Keywords

Transversalis Fascia Plane Block, Quadratus Lumborum Plane Block, Appendectomy, Pediatrics

Brief summary

This study aims to compare the effectiveness of ultrasound-guided Transversalis Fascia Plane block versus Quadratus Lumborum block for postoperative pain relief in pediatrics undergoing appendectomy. Primary outcomes: • Proportion of patients needing rescue analgesia within the first 24 postoperative hours. Secondary outcomes: * Visual Analogue Scale pain intensity measurements. * Intraoperative Heart rate and mean arterial blood pressure will be recorded. * Time to first analgesic request for patients needing rescue analgesia (Fentanyl). * Block-related complications (e.g., hematoma, local anesthetic toxicity, lower limb weakness). * Parents' satisfaction score.

Detailed description

Appendicectomy is amongst the most commonly performed surgery, with acute appendicitis being the most frequent reason for abdominal surgical emergencies in the world . The lifetime risk of appendicitis is 7-8%, with rising incidence in the newly industrialized countries . The prevailing treatment of choice for appendicitis is appendicectomy, which can be performed either 'open' or laparoscopically . A major contributor to the pain experienced by a patient after abdominal surgery is the incision made in the abdominal wall . Almost 80% of patients undergoing surgery experience postoperative pain, and 80% of them reported moderate-to-severe pain intensity . Traditional methods of postoperative pain management in children, such as systemic opioids and nonsteroidal anti-inflammatory drugs , may not always provide adequate relief, especially for more invasive procedures . These approaches can also be associated with side effects like sedation, nausea, and respiratory depression, which may complicate postoperative care and recovery . In recent years, regional anesthesia techniques have emerged as promising alternatives for postoperative pain management in various surgical populations Two specific regional blocks that have gained attention for their potential benefits in reducing postoperative pain after abdominal surgeries is the Quadratus Lumborum Block and the Transversus Facial Abdominal Plane block The Quadratus Lumborum Block targets the nerves supplying the lumbar plexus, providing analgesia to the anterior abdominal wall . It has been shown to be effective in adult patients undergoing lower abdominal surgery, offering improved postoperative pain scores and reduced opioid consumption compared to traditional pain management strategies . Although, both Quadratus Lumborum Block and Transversus Facial Abdominal Plane block are frequently employed in pediatric anesthesia, evidence to guide clinical decisions on which block offers superior outcomes needs to be comprehensively reviewed. We aimed to compare the effectiveness of ultrasound-guided Transversalis Fascia Plane block versus Quadratus Lumborum block for postoperative pain relief in pediatrics undergoing appendectomy. This study aims to compare the effectiveness of ultrasound-guided Transversalis Fascia Plane block versus Quadratus Lumborum block for postoperative pain relief in pediatrics undergoing appendectomy. Primary outcomes: • Proportion of patients needing rescue analgesia within the first 24 postoperative hours. Secondary outcomes: * Visual Analogue Scale pain intensity measurements. * Intraoperative Heart rate and mean arterial blood pressure will be recorded. * Time to first analgesic request for patients needing rescue analgesia (Fentanyl). * Block-related complications (e.g., hematoma, local anesthetic toxicity, lower limb weakness). * Parents' satisfaction score.

Interventions

35 Patients will receive general anesthesia and ultrasound-guided transversalis fascia plane block in a dose of 0.4 ml/kg of 0.25% bupivacaine administered prior to surgical excision.

PROCEDUREQuadratus Lumborum Plane Block group

35 patients will receive general anesthesia and a quadratus lumborum plane block in a dose of 0.4 ml/kg of 0.25% bupivacaine administered prior to surgical excision

Sponsors

Tanta University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
7 Years to 12 Years
Healthy volunteers
No

Inclusion criteria

* 70 patients aged between 7 and 12 years of both sexes undergoing appendectomy, American Society of Anesthesiologists (ASA) physical status of I or II

Exclusion criteria

* Refusal of parents to participate * Patients with peritonitis * History of allergy to bupivacaine and other amide local anesthetics * Infection at the site of block needle entry * Bleeding diathesis * Neurological disorders * American Society of Anesthesiologists ≥ III

Design outcomes

Primary

MeasureTime frame
Proportion of patients needing rescue analgesiawithin the first 24 postoperative hours.

Secondary

MeasureTime frameDescription
Visual Analogue Scale24 postoperative hoursVisual Analogue Scale pain intensity measurements.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 2, 2026