Insulin Sensitivity, Overweight Adolescents, Sleep
Conditions
Brief summary
Many teenagers get too little and late timed sleep. High body weight and diabetes are increasing in teenagers as well. This study plans to learn more about whether improving sleep habits can help improve how the body regulates blood sugar and energy use in teenagers who have higher body weight. To answer this question, the investigators plan to enroll teenagers who get \<7 hours of sleep on school nights and measure changes in blood sugars and energy use after two weeks of typical sleep (sleeping on their normal school schedule) and two weeks of a sleep intervention that includes spending longer time in bed at night, melatonin, and morning light.
Interventions
BEHAVIORALCircadian/Sleep (C/S)
1h additional time in bed, melatonin 2h before bedtime, and 30 minutes bright light after waking
Sponsors
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
14 Years to 19 Years
Healthy volunteers
No
Inclusion criteria
1. High school students between 14-19 years 2. Overweight/obesity (BMI \>85% for age and sex) 3. Have habitually insufficient sleep, defined as ≤ 7 hours per night on school days 4. Habitually inactive (≤ 3 h of physical activity reported per week) 5. Tanner stage 4 or 5, based on breast development for girls and testicular size for boys.
Exclusion criteria
1. Reported diagnosis of sleep disorder (e.g., insomnia, obstructive sleep apnea) 2. Medical comorbidities that impact sleep or insulin sensitivity (e.g., diabetes \[based on history or screening HbA1c\]) 3. Regular use of medications affecting sleep or insulin sensitivity (e.g., stimulants, sleep aids, systemic steroids, insulin sensitizers, GLP-1 agonists) 4. IQ\<70 or severe mental illness that may impact sleep or study participation (e.g., schizophrenia), eating disorder, or active suicidal ideation 5. Schedules that would preclude participants from adhering to the sleep schedules (e.g., night-shift employment)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | Assessed at 2 weeks following each condition | Matsuda Index will be calculated from a mixed meal tolerance test (MMTT); higher values indicate better insulin sensitivity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total daily energy expenditure (TDEE) | Assessed for two weeks during each condition | Assessed with doubly labeled water. Higher values indicate greater energy expenditure |
| Average daily caloric intake (kcal/day) | Measured for 3 days during each condition | Calculated from photographic diet diaries. Higher kcal indicates greater caloric intake. |
Contacts
CONTACTStacey L Simon, PhD
CONTACTAngel Arias, BS
PRINCIPAL_INVESTIGATORStacey L Simon
University of Colorado, Denver
Outcome results
None listed