Hyperthermia
Conditions
Brief summary
Our study has two goals. The first goal is to find a blood test that can detect signs of strain from heat in the body ("a biomarker"). Second, the study team wants to identify types of devices that can help people cool down quickly. By identifying biomarkers for heat strain, scientists can better track and treat the health effects of heat. The study team will identify such biomarkers by simulating, in a laboratory-based environment, the heat and physical work that real-world workers experience. In addition, the study team plans to test two cooling technologies that might keep people cool during physical activity.
Interventions
OTHERHand cooling table
A participant can rest their hand on the cooling table after the one hour exercise session, and this should cool their body quickly. Cold water is pumped throughout the cooling table.
OTHERCooling bandana
A participant will tie a bandana that has been soaked in cold water onto their forehead. They will wear this bandana during the one hour exercise session.
Sponsors
Stanford University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-50 * Able to communicate in English or Spanish * General good health * A lifestyle that includes regular patterns of modest exercise * Body weight over 80 pounds
Exclusion criteria
* Cannot provide informed consent * Known history of cardiac arrhythmias or having a pacemaker * Difficulty swallowing pills * Planned upcoming X-ray tests or MRI * Known history of gastroparesis, diverticulosis or diverticulitis, or inflammatory bowel disease * Previous surgery on stomach or intestines (except for appendix or gallbladder) * Pregnancy * Self-reported cardiac, kidney, or pulmonary disease, or diabetes * Concurrent use of temperature- or inflammation-modulating medications such as steroids or non-steroidal anti-inflammatory drugs (NSAIDs) * Staff under the direct supervision of any project directors or employed in the laboratory of the study investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Core body temperature | Baseline through end of study (approximately 2 months). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJulie Parsonnet, MD
Stanford University
Outcome results
None listed